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Breakthrough SARS-CoV-2 infections after vaccination: A critical review
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  • Zeinab Mohseni Afshar,
  • Mohammad Barary,
  • Feizollah Mansouri,
  • Soheil Ebrahimpour,
  • Kosar Nazary,
  • Terence Sio,
  • Mark Sullman,
  • Kristin Carson-Chahhoud,
  • Arefeh Babazadeh
Zeinab Mohseni Afshar
Kermanshah University of Medical Sciences
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Mohammad Barary
Babol University of Medical Science
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Feizollah Mansouri
Kermanshah University of Medical Sciences
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Soheil Ebrahimpour
Babol University of Medical Science
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Kosar Nazary
Babol University of Medical Science
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Terence Sio
Mayo Clinic Arizona
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Mark Sullman
University of Nicosia
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Kristin Carson-Chahhoud
University of South Australia
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Arefeh Babazadeh
Babol University of Medical Science

Corresponding Author:drbabazadeh.a@yahoo.com

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Abstract

At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination.