Maternal characteristics |
|
|
Age [mean (SD) years] |
33.3 (4.4) |
34.1 (4.8) |
Country of birth (Ireland) |
142 (88.2) |
139 (86.9) |
Ethnicity (white) |
156 (96.9) |
158 (98.8) |
Paternal characteristics |
|
|
Age [mean (SD) years] |
35.3 (5.7) |
35.9 (5.5) |
Country of birth (Ireland) |
142 (88.2) |
143 (89.4) |
Ethnicity (white) |
157 (97.5) |
159 (99.4) |
Infant characteristics |
|
|
Sex (male) |
79 (49.1) |
85 (53.1) |
Gestational age [mean (SD) weeks] |
39.7 (1.1) |
39.5
(1.1) |
Birth weight [mean (SD) kg] |
3.6 (0.4) |
3.6 (0.5) |
Mode of delivery |
|
|
Vaginal |
98 (61.3) |
103 (64.4) |
Caesarean section |
62 (38.8) |
57 (35.6) |
Age randomised [mean (SD) days] |
1.9 (1.0) |
1.8
(0.8) |
Baseline TEWL [median (IQR) gwater/m2/h] |
9.31 (7.25, 12.41) |
9.25
(7.44, 13.31) |
Baseline NMF [median (IQR) g/g
protein] |
0.32 (0.22, 0.42) |
0.33 (0.25, 0.41) |
Family history of atopy |
|
|
Maternal atopy |
|
|
Allergic rhinitis |
81 (50.3) |
63 (39.4) |
Atopic dermatitis |
40 (24.8) |
56 (35.0) |
Asthma |
54 (33.5) |
63 (39.4) |
Any maternal atopy |
112 (69.6) |
107 (67.3) |
Paternal allergy |
|
|
Allergic rhinitis |
66 (41.8) |
75 (47.2) |
Atopic dermatitis |
43 (27.2) |
45 (28.3) |
Asthma |
56 (35.4) |
53 (33.3) |
Any paternal atopy |
101 (63.9) |
107 (67.3) |
Two parents with atopic history |
52 (32.9) |
54 (34.2) |
Participant with at least one sibling |
87 (54.0) |
94
(58.8) |
Of which, at least one sibling with |
|
|
Allergic rhinitis
|
20 (23.0)
|
21 (22.3)
|
Atopic dermatitis
|
35 (40.2)
|
41 (43.6)
|
Asthma
|
12 (13.8)
|
13 (13.8)
|
FLG genotyping |
|
|
FLG wildtype
|
96/117 (82.1)
|
113/136 (83.1)
|
FLG null mutation (one)
|
21/117 (17.9)
|
22/136 (16.2)
|
FLG null mutation (two)
|
0
|
1/136 (0.7)
|