Mineralocorticoid receptors in major depressive disorder (MDD) and borderline personality disorder (BPD).
Several mental disorders are characterized by HPA axis dysfunction. In this review, we specifically focus on MDD and BPD as two examples of stress-associated disorders. Historically, research on corticoid receptor function in mental disorders is predominantly focused on GR alterations (Binder et al. , 2004; Martín-Blanco et al. , 2014). However, variations in the MR gene are commonly associated with negative memory bias, amygdala reactivity, and life adversity in mental disorders (Bogdan, Williamson and Hariri, 2012; Vogel et al. , 2016; Vinkers et al. , 2015) and altered aldosterone concentrations have been repeatedly found in MDD (Murck H, Büttner M, Kircher T, 2014; Nowacki, Wingenfeld, Kaczmarczyk, Chae, Salchow,et al. , 2020). Therefore, an association of the MR function with cognitive and emotional dysfunction is plausible.