Developing maculopapular rash >3 weeks starting with the
suspected drug.
Prolonged clinical symptoms 2 weeks after discontinuation of the
suspected drug
Fever >38 °C
Liver abnormalities (ALT>100U/L)*
Leucocyte abnormalities (at least one present) (a)Leukocytosis
(>11*10^9 /L) (b) Atypical
lymphocytosis(>5%) (c) Eosinophilia(>1,5
*10^9 /L)
Lymphadenopathy
Human Herpes 6 reactivation
Diagnosis is confirmed by the presence of the 7 criteria
(typical DIHS) or the five (1-5) (atypical DIHS). *: This can be
replaced by other organ involvement, such as renal involvement.
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