INTRODUCTION
Post-operative polyuria is a well-documented complication of prolonged
surgeries. The increased sympathetic drive during surgery leads to
stimulation of vasopressin and aldosterone. This stimulation, coupled
with the large amounts of intravenous fluid patients receive during
surgery, promotes fluid retention1. Decrease in the
levels of vasopressin and aldosterone after surgery causes release of
retained fluids leading to polyuria. However, polyuria can also be
caused by Diabetes Insipidus (DI). While, post-operative Diabetes
Insipidus can be transient or permanent depending on the extent of
injury to the pituitary gland and is most commonly associated with
pituitary surgeries2. Very few cases have been
reported after abdominal surgeries. Here we report the case of a
48-year-old woman who developed central DI due to prolonged abdominal
surgery with significant intraoperative blood loss.