2.3 Image Preprocessing and Regions of Interest (ROIs)
Segmentation
CT images were acquired according to standardized scanning protocols.
Preprocessing of the images before ROIs segmentation was performed by a
radiologist, and the mean standard deviation of the images was
normalized. Lesions of all slices were delineated on the CT images
manually by a radiologist who was blinded to the clinical information of
the patients, then all contours were reviewed by the other senior
radiologist. If the discrepancy was ≥5%, the senior radiologist decided
on the tumor borders. Examples of ROIs of CCSK and Wilms’ tumor were
shown in Supplementary Fig. 2 .