3.3 Genetic counseling
The unaffected family member (III-2) requested a premarital genetic counseling in the study to determine her HME-risk status. Since the genetic mode of HME is autosomal dominant inheritance, we suggested that her offspring could be less likely to get the HME associated gene variant from mother according to the Mendelian law when she marries to a healthy male. Differently, when the proband (Ⅲ-3) and the other affected individuals (Ⅲ-1) marry to a healthy female, the offspring of them suffering from this disease accounts for 50%.