3.3 Genetic counseling
The unaffected family member (III-2) requested a premarital genetic
counseling in the study to determine her HME-risk status. Since the
genetic mode of HME is autosomal dominant inheritance, we suggested that
her offspring could be less likely to get the HME associated gene
variant from mother according to the Mendelian law when she marries to a
healthy male. Differently, when the proband (Ⅲ-3) and the other affected
individuals (Ⅲ-1) marry to a healthy female,
the offspring of them suffering
from this disease accounts for 50%.