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Short term effect and effect on rate of lung function decline after surgery for neuromuscular or syndromic scoliosis
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  • Esther Veldhoen,
  • Anneloes de Vries,
  • Tom Schlosser,
  • Moyo Kruyt,
  • Ruben van Eijk,
  • Joyce Tersmette,
  • Erik H.J. Hulzebos,
  • Ludo van der Pol,
  • Roelie Wösten-van Asperen,
  • Cornelis van der Ent
Esther Veldhoen
Wilhelmina Children's Hospital University Medical Centre

Corresponding Author:e.s.veldhoen@umcutrecht.nl

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Anneloes de Vries
Wilhelmina Children's Hospital University Medical Centre
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Tom Schlosser
University Medical Centre Utrecht Department of Orthopedics
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Moyo Kruyt
University Medical Centre Utrecht Department of Orthopedics
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Ruben van Eijk
Julius Center for Health Sciences and Primary Care
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Joyce Tersmette
Wilhelmina Children's Hospital University Medical Centre
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Erik H.J. Hulzebos
Wilhelmina Children's Hospital University Medical Centre
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Ludo van der Pol
UMC Utrecht Brain Center Rudolf Magnus
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Roelie Wösten-van Asperen
UMC Utrecht - Locatie WKZ
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Cornelis van der Ent
Wilhelmina Children's Hospital University Medical Centre
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Abstract

Introduction Understanding the impact of scoliosis surgery on lung function is important for counseling patients about risks and benefits of surgery. We prospectively compared the trends in lung function test (LFT) results prior to and after scoliosis surgery in children with neuromuscular diseases, or dysmorphic syndromes. We hypothesized a stabilization. Methods We prospectively included children with neuromuscular or syndromic scoliosis able to perform LFTs. We studied (Forced) Vital Capacity ((F)VC), the ratio of Forced Expiratory Volume in 1 second (FEV1) and FVC, and Peak Expiratory Flow (PEF). Preoperative LFT results were compared with results 3-4 months after surgery. The mean monthly change in LFT results up to 2 years after surgery was compared with the preoperative natural history using linear mixed effects models. Results We included 43 patients. No significant change was observed in absolute values of (F)VC, FEV1/FVC and PEF prior to and after surgery. Median standardized VC, FVC and PEF decreased significantly after surgery from 59 to 58%, 60 to 51% and 61 to 53% respectively. The monthly rate of change in FVC was -0.13 % (95% CI -0.42 to 0.17) prior to surgery and -0.20% (95% CI -0.42 to 0.03) after surgery, mean difference -0.07 (95% CI -0.46 to 0.31; p=0.36). Conclusion No stabilization of lung function 3-4 months after scoliosis surgery was observed in children with neuromuscular and syndromic scoliosis with restrictive lung function disease. The effect of surgery on the rate of lung function decline remains inconclusive.
21 Sep 2021Submitted to Pediatric Pulmonology
23 Sep 2021Submission Checks Completed
23 Sep 2021Assigned to Editor
27 Sep 2021Reviewer(s) Assigned
05 Nov 2021Review(s) Completed, Editorial Evaluation Pending
08 Nov 2021Editorial Decision: Revise Major
02 Dec 20211st Revision Received
02 Dec 2021Submission Checks Completed
02 Dec 2021Assigned to Editor
02 Dec 2021Reviewer(s) Assigned
21 Dec 2021Review(s) Completed, Editorial Evaluation Pending
27 Dec 2021Editorial Decision: Revise Minor
18 Jan 20222nd Revision Received
19 Jan 2022Submission Checks Completed
19 Jan 2022Assigned to Editor
19 Jan 2022Reviewer(s) Assigned
02 Feb 2022Review(s) Completed, Editorial Evaluation Pending
04 Feb 2022Editorial Decision: Revise Minor
07 Feb 20223rd Revision Received
08 Feb 2022Submission Checks Completed
08 Feb 2022Assigned to Editor
08 Feb 2022Reviewer(s) Assigned
09 Feb 2022Review(s) Completed, Editorial Evaluation Pending
12 Feb 2022Editorial Decision: Accept
May 2022Published in Pediatric Pulmonology volume 57 issue 5 on pages 1303-1309. 10.1002/ppul.25857