Title: Pure White Cell Aplasia an exceptional condition in the inmunological conundrum of thymomas: Responses to inmunosupresion and Literature Review.
Authors: Céspedes López R1, Amutio Díez E2, Martín Martitegui X2, Balerdi Malcorra A2, Insunza Oleaga L3, Moreno Gámiz M2, Arzuaga Méndez J2, García-Ruíz JC2.
1Hematology, Banc de Sang i Teixits BST-GIRONA, Girona, Spain. 2Hematology, Hospital Universitario Cruces, Barakaldo, Spain 3 Hematology, Hospital San Eloy Barakaldo, Spain.
Corresponding Author : Roberto Céspedes López, Hematologist, Banc de Sang i Teixits BST-Girona, Girona, Spain. Email: rcespedes@bst.cat
Key Clinical Message: Pure White Cell Aplasia associated to thymoma is a rare autoinmune condition which no respond to treatment with G-CSF. It is neccesary the use of immunosuppressors to allow granulocyte recovery. Without treatment it could be fatal.
Abstract: Thymomas are tumours frequently associated with autoinmune manifestations or immunodeficiencies like Good syndrome. In rare cases, pure white cells aplasia (PWCA) has been described in association with thymomas. PWCA is characterized by agranulocytosis of autoinmune background primary refractory to granulocyte colony-stimulating factor (G-CSF). It is necessary to use inmunosupressor drugs.
Key Words: Thymoma, Pure White Cell Aplasia, Agranulocytosis, Granulocytopenia and Good’s Syndrome.