Title: Pure White Cell Aplasia an exceptional condition in the
inmunological conundrum of thymomas: Responses to inmunosupresion and
Literature Review.
Authors: Céspedes López R1, Amutio Díez
E2, Martín Martitegui X2, Balerdi
Malcorra A2, Insunza Oleaga L3,
Moreno Gámiz M2, Arzuaga Méndez J2,
García-Ruíz JC2.
1Hematology, Banc de Sang i Teixits BST-GIRONA,
Girona, Spain. 2Hematology, Hospital Universitario
Cruces, Barakaldo, Spain 3 Hematology, Hospital San
Eloy Barakaldo, Spain.
Corresponding Author : Roberto Céspedes López, Hematologist,
Banc de Sang i Teixits BST-Girona, Girona, Spain. Email:
rcespedes@bst.cat
Key Clinical Message: Pure White Cell Aplasia associated to
thymoma is a rare autoinmune condition which no respond to treatment
with G-CSF. It is neccesary the use of immunosuppressors to allow
granulocyte recovery. Without treatment it could be fatal.
Abstract: Thymomas are tumours frequently associated with
autoinmune manifestations or immunodeficiencies like Good syndrome. In
rare cases, pure white cells aplasia (PWCA) has been described in
association with thymomas. PWCA is characterized by agranulocytosis of
autoinmune background primary refractory to granulocyte
colony-stimulating factor (G-CSF). It is necessary to use
inmunosupressor drugs.
Key Words: Thymoma, Pure White Cell Aplasia, Agranulocytosis,
Granulocytopenia and Good’s Syndrome.