|
Unmatched/unadjusted |
Unmatched/unadjusted |
Unmatched/unadjusted |
Unmatched/unadjusted |
Unmatched/unadjusted |
Unmatched/unadjusted |
Unmatched/unadjusted |
Matched/adjusted1
|
Matched/adjusted1
|
Matched/adjusted1
|
Matched/adjusted1
|
Matched/adjusted1
|
Matched/adjusted1
|
Matched/adjusted1
|
Matched/adjusted1
|
|
Frequentist |
Frequentist |
Frequentist |
|
Bayesian |
Bayesian |
Bayesian |
Frequentist |
Frequentist |
Frequentist |
|
Bayesian |
Bayesian |
Bayesian |
Bayesian |
|
GMR (95%CI) |
|
P |
|
GMR (95%CrI) |
|
P(GMR≠1.0); P |
GMR
(95%CI) |
|
P |
|
GMR (95%CrI) |
|
P(GMR≠1.0); P |
|
AUCτ,ss (mg•hr/L) |
1.45 (1.10-1.92) |
|
0.009 |
|
1.38 (1.07-1.81) |
|
99.2%; 0.016 |
1.41 (1.11-1.79) |
|
0.011 |
|
1.39 (1.05-1.81) |
|
99.0%; 0.020 |
|
Cmax,ss (mg/L) |
1.01 (0.71-1.44) |
|
0.940 |
|
1.01
(0.74-1.39) |
|
53.3%; 0.934 |
1.16 (0.80-1.68) |
|
0.381 |
|
1.10
(0.78-1.52) |
|
72.1%; 0.557 |
|
C0 (mg/L) |
1.66 (0.99-2.79) |
|
0.056 |
|
1.39
(0.91-2.11) |
|
93.7%; 0.126 |
1.23 (0.62-2.41) |
|
0.517 |
|
1.32
(0.86-2.08) |
|
88.9%; 0.222 |
|
C12 (mg/L) |
1.57 (0.88-2.81) |
|
0.123 |
|
1.30
(0.84-2.06) |
|
87.8%; 0.243 |
1.21 (0.60-2.41) |
|
0.560 |
|
1.28
(0.81-2.06) |
|
84.5%; 0.310 |
|
CLT/F,ss (mL/min/kg) |
0.66 (0.48-0.90) |
|
0.010 |
|
0.71 (0.53-0.95) |
|
98.9%; 0.022 |
0.73 (0.58-0.93) |
|
0.016 |
|
0.71 (0.54-0.95) |
|
98.8%; 0.024 |
|
Cmax/AUCτ (1/h) |
0.70 (0.50-0.96) |
|
0.029 |
|
0.75 (0.55-0.99) |
|
97.5%; 0.050 |
0.81 (0.57-1.14) |
|
0.193 |
|
0.81 (0.60-1.15) |
|
89.6%; 0.208 |
|