Variant carriers Wild type
N 12 56
Men 6 (50.0) 30 (53.6)
Age (years) 46.5±13.3 (26-68) 50.5±12.8 (16-71)
Body mass index (kg/m2) 24.9±6.3 (17.7-39.5) 24.0±3.3 (14.5-30.4)
Mycophenolate mofetil 2 (16.7) 21 (37.5)
1000 mg bid
1
17
750 mg bid
0
2
500 mg bid
1
2
Enteric coated mycophenolate 10 (83.3) 35 (62.5)
Daily dose (mg)
All 720 mg bid
All 720 mg bid
Cyclosporine A 6 (50.0) 37 (66.1)
Morning dose (mg/kg)
160 (144-175; 125-175)
150 (125-188; 75-250)
Evening dose (mg/kg)
162 (125-181; 125-200)
150 (125-200; 75-250)
Morning trough (µg/L)
212±53 (169-311)
204±64 (70-341)
Tacrolimus 6 (50.0) 19 (33.9)
Morning dose (mg)
2.0 (1.7-3.9; 1.0-5.0)
3.0 (2.5-3.0; 1.5-4.0)
Evening dose (mg)
3.3 (2.2-4.3; 1.5-5.0)
3.0 (3.0-4.0; 2.0-4.0)
Morning trough (µg/L)
11.0±3.2 (7.8-16.9)
10.8±5.8 (3.4-27.4)
Prednisone equivalent (mg/day) 40 (30-40; 30-60) 35 (30-47; 20-75)
Urine output (L/day) 2.4 (2.1-2.6; 1.8-4.3) 2.6 (2.1-3.2; 1.1-5.7)
Estimated creatinine clearance (mL/min) 45±16 (29-84) 41±11 (23-74)
CYP3A4*22 genotype
*1/*1
12 (100)
55 (98.2)
*1/*22
0
1 (1.8)
CYP3A5*3 genotype
*3/*3
11 (91.7)
48 (85.7)
*1/*3
1 (8.3)
8 (14.3)
UGT2B7 -161C>T genotype
Variant allele
9 (75.0)
47 (83.9)
Wild type
3 (25.0)
9 (16.1)
UGT1A9 -275 / -2152 diplotype
Variant allele
0
3 (5.4)
Wild type
12 (100)
53 (94.6)
ABCB1 2677 / 3435 / 1236 diplotype
Wild type or 1 variant allele
3 (25.0)
15 (26.8)
2-3 variant alleles
6 (50.0)
25 (44.6)
4-6 variant alleles
3 (25.0)
16 (28.6)
SLC01B1 521T>C genotype
Variant allele
4 (33.3)
21 (37.5)
Wild type
8 (66.7)
35 (62.5)
ABCC2 -24 C>T genotype
Variant allele
2 (16.7)
19 (33.9)
Wild type
10 (83.3)
37 (66.1)
ABCC2 1249 G>A genotype
Variant allele
4 (33.3)
23 (41.1)
Wild type
8 (66.7)
33 (58.9)
Donor’s ABCC2 1249 G>A genotype
Variant allele
6 (50.0)
21 (37.5)
Wild type
6 (50.0)
35 (62.5)