AUCt,ss – area under the concentration-time curve during dosing interval at steady-state; BMI – body mass index; Cmax,ss – peak plasma concentration at steady-state; C0 – morning pre-dose trough; C12 – evening trough; CLT/Fss – apparent total body clearance at steady-state; CNI – calcineurin inhibitor; EC-MPS – enteric-coated mycophenolate sodium; eCrCl – estimated creatinine clearance; MMF – mycophenolate mofetil
1Linear transformation to ln(cyclosporine trough) scale
Table 5 Comparison of pharmacokinetic parameters betweenABCG2 c.421C>A variant allele carriers and wild type homozygotes (as geometric means ratios, GMR for variant/wild type) in the entire data set (unmatched and unadjusted) and in matched data set (with additional adjustment).