AUC_t,ss – area under the concentration-time curve during dosing interval at steady-state; BMI – body mass index; C_max,ss – peak plasma concentration at steady-state; C₀ – morning pre-dose trough; C₁₂ – evening trough; CL_T/Fss – apparent total body clearance at steady-state; CNI – calcineurin inhibitor; EC-MPS – enteric-coated mycophenolate sodium; eCrCl – estimated creatinine clearance; MMF – mycophenolate mofetil

¹Linear transformation to ln(cyclosporine trough) scale

Table 5 Comparison of pharmacokinetic parameters betweenABCG2 c.421C>A variant allele carriers and wild type homozygotes (as geometric means ratios, GMR for variant/wild type) in the entire data set (unmatched and unadjusted) and in matched data set (with additional adjustment).