AUCt,ss – area under the concentration-time curve
during dosing interval at steady-state; BMI – body mass index;
Cmax,ss – peak plasma concentration at steady-state;
C0 – morning pre-dose trough; C12 –
evening trough; CLT/Fss – apparent total body clearance
at steady-state; CNI – calcineurin inhibitor; EC-MPS – enteric-coated
mycophenolate sodium; eCrCl – estimated creatinine clearance; MMF –
mycophenolate mofetil
1Linear transformation to ln(cyclosporine trough)
scale
Table 5 Comparison of pharmacokinetic parameters betweenABCG2 c.421C>A variant allele carriers and
wild type homozygotes (as geometric means ratios, GMR for variant/wild
type) in the entire data set (unmatched and unadjusted) and in matched
data set (with additional adjustment).