Abstract
Chorioamnionitis is an acute inflammation of the membranes and chorion
of the placenta typically due to ascending polymicrobial infection in
the setting of membrane rupture. It is a common complication of
pregnancy associated with significant maternal, perinatal, and long-term
adverse outcomes. We present a case of placental infection leading to
preterm delivery, severe neonatal sepsis, maternal wound infection,
postnatal readmission, and prolonged hospital stay. This virulent
infection was caused by multi-drug resistant Extended Spectrum Beta
Lactamase (ESBL)-producing Escherichia Coli (E. Coli), which represent a
major world-wide threat according to the Centre for Disease Control and
Prevention (CDC). It was managed with appropriate antibiotic therapy,
patient-centred approach and multidisciplinary team involvement that led
to favourable maternal and neonatal outcome.
Keywords: Chorioamnionitis, wound infection, neonatal sepsis,
extended spectrum beta-lactamase; E. Coli