Cup Like acute myeloid leukemia is the rarest form of children leukemia. We present a case of Cup Like Acute Myeloid Leukemia (AML) with t(4;12) (q12;p13) associated with two other clones t(1;16)(q12;q24) and t(12;13)(p13;q13). Cytogenetic and iFISH are highly relevant for the prognosis of and therapeutic decisions in LAM.

Myoclonus-Dystonia is a neuropsychiatric disorder with autosomal dominant mode of inheritance with variable severity and incomplete penetrance. Pathogenic variants in SGCE are the most frequent genetic cause of M-D with maternal imprinting. Herein we report a new deleterious variant based on protein modeling analysis (c.662G> T) inherited in moroccan family.