Patient with anti-NMDAR encephalitis have increase NLRP3 and IL-1β in CSF
To verify NLRP3 activation in the brain, NLRP3 inflammasome and IL-1β were detected in patients with anti-NMDAR encephalitis and in control subjects. Clinical features of control subjects and patients with anti-NMDAR encephalitis are present in Table 1. Results showed that levels of NLRP3 inflammasome (Fig 5A) and IL-1β (Fig 5B) were remarkably increased in patients with anti-NMDAR encephalitis when compared to that in controls.