Figure 3. MOG35-55-indcued neuroinflammation
depends on JAK2 signaling. A, HE staining of mouse brain after
induction of EAE in the absence or presence of ruxolitinibapplication.
B, CD4 staining of mouse brain (n=3 each group). C, LFB staining of
mouse brain. D, Expression of NLRP3 and MBP of mouse brain (n=3 each
group). E, Determination of IL-1β in mouse brain (n=4 each group). F,
Determination of TSLP in mouse brain (n=4 each group). Data were
presented as mean±SEMin a high-power field (HPF)
(*p <0.05, **p <0.01,
***p <0.001)