Th22 cells were associated with Th17 and TNF-α production in KD patients
We analyzed the relationship among the numbers of circulating Th22, Th17 and TNF-α in KD patients. We found that the numbers of Th22 cells were significantly positively correlated with the numbers of Th17 cells in KD patients with CAL (R =0.494, P =0.044, Fig. 3A). Further analysis revealed that the numbers of circulating Th22 and Th17 cells were correlated positively with the levels of serum IL-22 and IL-17A in KD patients with CAL, respectively (R =0.647, P =0.005, Fig. 3B; R = 0.774, P =0.003, Fig. 3D). In addition, the numbers of circulating Th22 cells were correlated positively with the levels of serum TNF-α in KD patients with CAL (R = 0.756,P< 0.001, Fig. 3C). Moreover, KD patients with NCAL also showed the same trend (R =0.522, P =0.006, Fig. 3E;R =0.676, P =0.002, Fig. 3F; R =0.643,P< 0.001, Fig. 3G; R =0.491, P =0.011, Fig. 3H; respectively).