Th22 and Th17 cells were associated with clinical parameters in KD patients
To determine the pathogenic role of Th22 and Th17 cells in the development of KD, we analyzed the potential association of the levels of these CD3+CD4+T cell-related cytokines with the values of clinical parameters in KD patients. We found that the concentrations of serum IL-22 and IL-17 were correlated positively with the concentrations of ESR, CRP and NT-proBNP in KD patients with CAL, respectively (R =0.653, P =0.005;R =0.506, P =0.038; R =0.609, P= 0.009, Fig. 4A;R =0.743, P< 0.001; R =0.837,P< 0.001; R =0.597, P =0.011, Fig. 4B; respectively). Moreover, KD patients with NCAL also showed the same trend (R =0.753, P< 0.001; R =0.504,P =0.009; R =0.406, P= 0.039, Fig. 4C; R =0.561,P= 0.003; R =0.444, P= 0.023; R =0.492,P =0.011, Fig. 4D; respectively).