2.3. Statistical Analysis:
Mean and standard deviation were used to describe quantitative data and frequency and percentage were used to describe categorical data. ANCOVA test was used to evaluate the effect of silymarin on quantitative variables (EORTC QLQ and VAS) so that the final EORTC QLQ and VAS scores were used as the main factor and adjusted based on the initial score. Chi-square test was used to describe the qualitative outcomes (e.g., severity of neuropathy and number of patients improved). All tests were calculated at 95% significance level using SPSS software version 21.