What is already known about this topic?
- Chemotherapy-induces peripheral neuropathy is a common complication of
chemotherapy agents with a significant impact on patients’ quality of
life.
- Oxidative stress and inflammation has a critical role in the
development of chemotherapy-induces peripheral neuropathy.
- Silymarin was effective in reducing chemotherapy-induced neuropathic
pain in animal studies.What does this article add?
- Silymarin significantly reduced the severity of chemotherapy-induces
peripheral neuropathy as measured by Common Terminology Criteria for
Adverse Events (P= 0.005).
- The silymarin-treated group showed a significant reduction in pain
compared with those receiving placebo (P= 0.001).
- The frequency of adverse effects of silymarin was similar to placebo.