Epitope |
Anti-RBD |
Anti-S1 |
Anti-N |
Anti-N |
Anti-N |
Anti-S1/S2 |
Anti-RBD+ |
Antibody subtype |
IgG |
IgG |
IgG |
Pan-Ig |
IgG |
IgG |
Pan-Ig |
Manufacturer |
In-house |
Euroimmun |
Epitope diagnostics |
Roche diagnostics |
Abbott |
DiaSorin |
Bühlmann |
Numbers of patients |
3’637 |
3’658 |
3’654 |
3’630 |
3’630 |
3’630 |
2’589 |
True positives |
152 |
168 |
126 |
164 |
153 |
160 |
110 |
False negatives |
40 |
27 |
66 |
25 |
36 |
29 |
21 |
False positives |
98 |
62 |
79 |
54 |
60 |
84 |
95 |
True negatives |
3’347 |
3’401 |
3’383 |
3’387 |
3’381 |
3’357 |
2’363 |
AUC (95% CI)
|
0.95
(0.93, 0.97)
|
0.97
(0.95, 0.98)
|
0.90
(0.86, 0.93)
|
0.94
(0.91, 0.97)
|
0.95
(0.93, 0.98)
|
0.95
(0.92, 0.97)
|
0.92
(0.88, 0.95)
|
Sensitivity
(percent; 95%CI)
|
79.2
(72.7, 84.7)
|
86.2
(80.5, 90.7)
|
65.6
(58.4, 72.3)
|
86.8
(81.1, 91.3)
|
81.0
(74.6, 86.3)
|
84.7
(78.7, 89.5)
|
84.0
(76.6, 89.8)
|
Specificity
(percent; 95%CI)
|
97.2
(96.5, 97.7)
|
98.2
(97.7, 98.6)
|
97.7
(97.2, 98.2)
|
98.4
(98.0, 98.8)
|
98.3
(97.8, 98.7)
|
97.6
(97.0, 98.1)
|
96.1
(95.3, 96.9)
|
Positive likelihood ratio |
28 |
48 |
29 |
55 |
46 |
35 |
22 |
Negative likelihood ratio |
0.21 |
0.41 |
0.35 |
0.13 |
0.19 |
0.16 |
0.17 |