ORIGINAL ARTICLE
Serological testing for SARS-CoV-2 antibodies in clinical practice: a
comparative diagnostic accuracy study
Michael P. Horn, PhD1*, Hulda R. Jonsdottir, PhD2,3,8*, Daniel Brigger, PhD 2,3,
Lauro Damonti, MD4,5, Franziska Suter-Riniker,
PhD6, Olga Endrich, MD7, Tanja K.
Froehlich, PhD1, Martin Fiedler, MD1Carlo R. Largiadèr, PhD1, Jonas Marschall,
MD4, Benjamin Weber, PhD8, Alexander
Eggel, PhD2,3, Michael Nagler,
PhD1,3
1 University Institute of Clinical Chemistry,
Inselspital University Hospital, 3010 Bern, Switzerland;2 Department of Rheumatology, Immunology, and
Allergology, Inselspital University Hospital, 3010 Bern, Switzerland;3 Department of BioMedical Research, University of
Bern, 3012 Bern, Switzerland; 4 Department of
Infectious Diseases, Bern University Hospital, and University of Bern,
3012 Bern, Switzerland; 5 Ente Ospedaliero Cantonale,
Division of Infectious Diseases, Regional Hospital Lugano, 6900 Lugano,
Switzerland; 6 Institute for Infectious Diseases,
University of Bern, 3012 Bern, Switzerland; 7 Medical
Directorate, Inselspital, University Hospital of Bern, 3010 Berne,
Switzerland; 8 Spiez Laboratory, Federal Office for
Civil Protection, 3700 Spiez, Switzerland
* contributed equally
Correspondence: Michael Nagler, MD, PhD, MSc;
michael.nagler@insel.ch;
phone +41 31 664 0520; fax +41 31 632 4862
Keywords : Infections/*epidemiology/transmission *Disease
Outbreaks; spike
protein, SARS-CoV-2 [Supplementary Concept];
severe acute
respiratory syndrome coronavirus 2 [Supplementary Concept];
COVID-19 diagnostic testing [Supplementary Concept]
Running head: Serological testing for COVID-19
Word counts: text = 3940; abstract = 417; References = 38;
Figures = 6; Tables = 4