Impact of Metabolic Syndrome And Metabolic Syndrome Components on Tumor
Aggresiveness of Renal Cell Carcinoma
Abstract
Objective: The objective of this study was to evaluate the effects of
Metabolic Syndrome (MetS) and MetS components on tumor size, Fuhrman
grade and pathological T stage in renal cell carcinoma (RCC). Materials
and Methods: The data of 151 patients who were operated for RCC between
January 2010 and April 2018 were retrospectively reviewed according to
the he National Cholesterol Education Program Adult Treatment Panel III
(NCEP ATP III), and the effects of MetS and its components on tumor
size, Fuhrman grade and pathological T stage were comparatively
investigated. Results: Of the 151 patients operated for RCC in our
clinic, 27.2% had MS, 29.1% had diabetes mellitus (DM), 41% had
hypertension (HT), 68.3% had low high-density lipoprotein (HDL), 41%
had elevated triglyceride (TGL) elevation, and 27.2% had obesity. It
was found that the size of the tumor was statistically significantly
increased in the presence of the metabolic criteria examined. There was
a statistically significant increase in the Fuhrman grade of the
patients with MetS, DM, low HDL, high TGL and obesity. In the presence
of clinical conditions such as HT, low HDL and high TGL, there was a
statistically significant increase in the pathological T stage.
Conclusion: In patients undergoing surgery for RCC, MetS and its
components had a statistically significant correlation with tumor size,
Fuhrman grade, and pathological stage. If our results are supported by
further studies, the correlation between MetS and RCC could be revealed
more clearly.