Statistical methods
For between timepoint statistical comparisons, parametric variables (SPT wheal size, HRQL) were analyzed using paired t-test with data summarized as mean and standard deviation (SD). Non-parametric variables (sIgE, sIgG4) were analyzed using Wilcoxon rank-sum test with data summarized as median and inter-quartile range (IQR) and standard t-test on logarithmic scaled values with data summarized as geometric mean and 95% confidence interval (95% CI). The number and percentage of participants who achieved desensitization and SU were presented for all enrolled participants (intention-to-treat) and those who had an end-of-treatment DBPCFC outcome (complete case population). Persistence of SU was expressed as the proportion of participants with SU at T3 who maintained SU at 3-years post-treatment (T5). For HRQL outcomes, primary analysis used all available data at all time points. Robustness of findings and impact of missingness was investigated with a sensitivity analysis of complete series data to T4. P < 0.05 was statistically significant. Statistical analyses were performed using Stata release 15 software (StataCorp, College Station, Tex) and R (R version 3.6.1).