Open Thoracoabdominal Aortic Aneurysm Repair in Cardiopulmonary Testing
Era: A Correlative Cohort Analysis
Abstract
Background: Initial clinical evaluation (ICE) is
traditionally considered a useful screening tool to identify frail
patients during the pre-operative assessment. However, emerging evidence
supports the more objective assessment of cardiorespiratory fitness
(CRF) via cardiopulmonary exercise testing (CPET) to improve surgical
risk stratification. Herein, we compared both subjective and objective
assessment approaches to highlight the interpretive idiosyncrasies.
Methods: As part of routine pre-operative patient
contact, patients scheduled for major surgery were prospectively
‘eyeballed’ (ICE) by two experienced clinicians prior to more detailed
history taking that also included American Society of Anaesthesiologists
score classification. Each patient was subjectively judged to be either
‘frail’ or ‘not frail’ by ICE and ‘fit’ or ‘unfit’ from thorough review
of the medical notes. Subjective data were compared against the more
objective validated assessment of post-operative outcomes using
established CPET ‘cut-off’ metrics incorporating peak pulmonary oxygen
uptake ( V̇O 2PEAK), V̇O 2
at the anaerobic threshold ( V̇O 2-AT) and
ventilatory equivalent for carbon dioxide that collectively informed
risk stratification. These data were retrospectively extracted from a
single-centre prospective National Health Service database. Data were
analysed using the Chi-square automatic interaction detection decision
tree method. Results: A total of 127 patients examined
that comprised 58 % male and 42 % female patients aged 69 ± 10 y with
a BMI of 29 ± 7 kg/m 2. Patients were poorly
conditioned with a peak pulmonary oxygen uptake almost 20 % lower than
that predicted for age, sex-matched healthy controls with 35 %
exhibiting a V̇O 2-AT <11 mL/kg/min.
Disagreement existed between the subjective assessments of risk with
~34 % of patients classified not frail on ICE were
considered unfit by notes review ( P < 0.0001).
Furthermore, ~35 % of patients considered not frail on
ICE and ~31 % of patients considered fit by notes
review exhibited a V̇O 2-AT <11
mL/kg/min and of these, ~28 % and ~19
% were classified as intermediate-to-high risk.
Conclusions: These findings highlight the interpretive
limitations associated with the subjective assessment of patient frailty
with surgical risk classification underestimated in up to a third of
patients compared to the validated assessment of CRF. They reinforce the
benefits of a more objective and integrated approach offered by CPET
that may help improve perioperative risk assessment and better direct
critical care provision in patients scheduled for ‘high-stakes’ surgery
including open TAAA repair.