Animal models
To further evidence the role of MR activation and the beneficial effects
of MR blockade in CV diseases in more detail, researchers performed
classical experiments employing MRA in pathological animal models
(Riehle and Bauersachs, 2019), and also created dedicated mice with
cell-specific MR deletion or overexpression. The study of these models
has allowed analyzing the cellular and molecular mechanisms underlying
the beneficial effects of MR blockade and has led to the identification
of new potential pharmacological targets in the aldosterone/MR system.