Endothelial cell MR overexpression model
Endothelial cell-restricted overexpression of the MR increased the contractile response of mesenteric arteries and increased blood pressure in response to hypertensive agents (Cat et al., 2010). Endothelial cell-specific MR overexpression in mice reduced atrial thrombus formation after ferric chloride injury (Lagrange et al., 2014) suggesting a role for endothelial cell MR as an antithrombotic factor.