|
Binding |
Binding |
Binding |
Binding |
Binding |
Binding |
AVP-induced cAMP inhibition |
AVP-induced cAMP inhibition |
AVP-induced
cAMP inhibition |
AVP-induced cAMP inhibition |
AVP-induced cAMP
inhibition |
AVP-induced cAMP inhibition |
|
Ki
nM
|
Ki
nM
|
Ratio Ki
|
pKi
|
SEM
|
n
|
Ki
nM
|
Ki
nM
|
Ratio
Ki
|
pKi
|
SEM
|
n
|
MQ1 |
5.02 |
|
- |
8.44 |
0.1 |
25 |
41 |
|
1 |
7,42 |
0,05 |
16 |
MQ2 |
8.16 |
|
1.6 |
8.17 |
0.15 |
4 |
98 |
|
2.4 |
7,04 |
0,1 |
3 |
MQ3 |
13.3 |
|
2.6 |
7.92 |
0.14 |
4 |
198 |
*** |
4.8 |
6,71 |
0,07 |
3 |
MQ4 |
7.34 |
|
1.5 |
8.27 |
0.21 |
5 |
12 |
|
0.3 |
7,97 |
0,1 |
3 |
MQ5 |
3.50 |
|
0.7 |
8.58 |
0.3 |
4 |
9 |
|
0.2 |
8,17 |
0,3 |
5 |
MQ6 |
21.5 |
* |
4.3 |
7.60 |
0.1 |
5 |
251 |
*** |
6.1 |
6,66 |
0,2 |
3 |
MQ7-8 |
3.14 |
|
0.6 |
8.53 |
ND |
2 |
25 |
|
0.6 |
7,65 |
0,2 |
3 |
MQ9 |
45.1 |
** |
9.0 |
7.35 |
ND |
2 |
48 |
|
1.2 |
7,35 |
0,1 |
3 |
P19859 |
7.87 |
|
1.6 |
7.93 |
0.08 |
4 |
91 |
|
2.2 |
7,07 |
0,1 |
3 |
Q5ZPJ7 |
112 *** |
112 *** |
22.2 |
6.97 |
0.08 |
4 |
61 |
|
1.5 |
7,27 |
0,1 |
3 |
E7FL11 |
>>1000 |
>>1000 |
|
<<5 |
|
2 |
ND |
ND |
|
|
|
|
B4ESA3 |
>>1000 |
>>1000 |
|
<<5 |
|
2 |
ND |
ND |
|
|
|
|
C1IC51 |
>>1000 |
>>1000 |
|
<<5 |
|
2 |
ND |
ND |
|
|
|
|
D5J9Q8 |
>>1000 |
>>1000 |
|
<<5 |
|
2 |
ND |
ND |
|
|
|
|
F8J2F6 |
>>1000 |
>>1000 |
|
<<5 |
|
2 |
ND |
ND |
|
|
|
|
D-DTx |
>>1000 |
>>1000 |
|
<<5 |
|
2 |
ND |
ND |
|
|
|
|
DTx-K |
>>1000 |
>>1000 |
|
<<5 |
|
2 |
ND |
ND |
|
|
|
|
α-DTx |
>>1000 |
>>1000 |
|
<<5 |
|
2 |
ND |
ND |
|
|
|
|
DTx-I |
>>1000 |
>>1000 |
|
<<5 |
|
2 |
ND |
ND |
|
|
|
|
Calci |
>>1000 |
>>1000 |
|
<<5 |
|
2 |
ND |
ND |
|
|
|
|
BPTI |
>>1000 |
>>1000 |
|
<<5 |
|
2 |
ND |
ND |
|
|
|
|