3.6∣25-μg DNA vaccine patches suppressed total IgE production and increased For t 2-specific IgG2a with both therapeutic and prophylactic approaches
The left panels of Figure 3A and 3B show a scatter plot for the final total IgE profiling from an individual mouse at week 6 or 8, respectively. For both the therapeutic and the prophylactic approach, SV25-T and SV25-P groups showed significantly less total IgE production compared with the NV-T and NV-P groups. Moreover, the SV25-T group had higher level of For t 2-specific IgG2a antibodies than the respective non-vaccinated groups at week 6. The levels of For t 2-specific IgG2a at SV25-P group reached statistical significance at week 8 (right panels of Figure 3A and 3B).