Conclusions
This prospective cohort study confirms the previous observations on
changes in sCr values in pregnancy with thresholds for normal and
abnormal values almost similar to those observed in completely different
geographical and ethnic settings. The rapid decrease in early pregnancy
sCr and differences across trimesters need to be taken into account
during clinical practice while interpreting sCr in pregnancy. Extension
of prospective studies from early pregnancy to late infancy will provide
confirmatory data on the upper threshold values for sCr as a biomarker
of adverse pregnancy outcomes.