Another practical approach is to assess eBC management in those cases with SARS-CoV-2 test results available (positive or negative) and a more controversial clinical scenario (Table 2).
 

Consider using Point of Care (POC) antigen tests if PCR unavailable? In what situations?

Antigen-detection for the diagnosis of SARS-CoV2 using point-of-care tests (POC) provides a workable solution that could enable patients to self-isolate earlier and reduce the spread of infection 17, representing an option which is accessible to most outbreak areas compared with standard nucleic acid amplification tests (NAATs), such as RT-PCR assays 18. However, the trade-off is a loss of sensitivity compared to NAATs, particularly among asymptomatic patients 44. These tests should be carried out by trained professionals.
The POC antigen test is a viable when RT-PCR is unavailable in the following scenarios 18:
●        Patients presenting with 5–7-day onset of symptoms;
●        Positive results need confirmation by RT-PCR assays (ideally);
●        Outbreak areas and remote settings, where POC testing constitute an alternative to RT-PCR.

Consider using Point of Care (POC) antibody tests if PCR was unavailable? In what situations?

Serology tests have limited application diagnosis-wise, particularly in the acute phase  45, as most patients will develop an antibody response within 1 to 3 weeks after infection 19. Crucial windows of opportunity for clinical intervention and isolation measures may have already been missed  19.
There is also a possibility of cross-reaction with other pathogens, such as other human coronaviruses, increasing the odds for false positives 45. There was no consensus among the experts regarding the clinical utility of POC antibody tests. Some authors agreed this technology could be considered in some situations, despite its limitations in order to 19:
●        determine the extent of infection in patients not diagnosed using RT-PCR
●        determine infection fatality rate
●        support the development of vaccines