Inclusion and exclusion criteria
Patients included in this study, were those who met the clinical criteria for the diagnosis of neurofibromatosis; according to the 1988 National Institute of Health (NIH) consensus report 3334, with or without confirmed histopathological diagnosis of nodular or plexiform neurofibromas or other orbito-ocular or intracranial tumours, associated with neurofibromatosis. On the other hand, cases excluded, were those in whom, there was insufficient clinical evidence to meet the diagnostic criteria for NF, as well as, those with histopathological tissue biopsies supporting a different clinical diagnosis.