loading page

“Multiple Lineage-switches in a pediatric case with a KMT2A-AFF1 positive Acute Lymphoblastic Leukemia:
  • +3
  • Luca Lo Nigro,
  • Marta Arrabito,
  • Emanuela Cannata,
  • Manuela La Rosa,
  • Valeria Iachelli,
  • Paola Bonaccorso
Luca Lo Nigro
Azienda Ospedaliero Universitaria Policlinico G Rodolico San Marco

Corresponding Author:lucalonigro1968@gmail.com

Author Profile
Marta Arrabito
Azienda Ospedaliero Universitaria Policlinico G Rodolico San Marco
Author Profile
Emanuela Cannata
Azienda Ospedaliero Universitaria Policlinico G Rodolico San Marco
Author Profile
Manuela La Rosa
Azienda Ospedaliero Universitaria Policlinico G Rodolico San Marco
Author Profile
Valeria Iachelli
Azienda Ospedaliero Universitaria Policlinico G Rodolico San Marco
Author Profile
Paola Bonaccorso
Azienda Ospedaliero Universitaria Policlinico G Rodolico San Marco
Author Profile

Abstract

We report a case with multiple lineage switches, a rare event that mostly occurred in infants, in a ten-year-old girl with KMT2A-AFF1 positive ALL. Although she received standard chemotherapy, immunotherapy and hematopoietic stem cell transplantation (HSCT), the leukemic clone continuously switched on AML or ALL, maintaining immunoglobulin/T-cell receptor (IG/TR) rearrangements and showing a high grade of therapy-escaping. Since other genes are involved in this event, considering the selective pressure imposed by the applied treatment, it is mandatory to characterize the cell-of-origin that is capable to proliferate towards both lineages in the attempt to design a targeted therapy.