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Severe thrombocytopenia caused by vancomycin in the intensive care unit: a case report and systematic review
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  • Guanru Wang,
  • Xiao-Xiao LI,
  • Qing-gang Ge,
  • Chao Li,
  • Na He,
  • Peng Yao,
  • Chuhui Wang,
  • Min Yi,
  • Zongyu Wang,
  • Luwen Shi,
  • Rongsheng Zhao
Guanru Wang
Peking University Third Hospital
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Xiao-Xiao LI
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Qing-gang Ge
Peking University Third Hospital
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Chao Li
Peking University Third Hospital
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Na He
Peking University Third Hospital
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Peng Yao
Peking University School of Pharmaceutical Sciences
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Chuhui Wang
Peking University Third Hospital
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Min Yi
Peking University Third Hospital
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Zongyu Wang
Peking University Third Hospital
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Luwen Shi
Peking University School of Pharmaceutical Sciences
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Rongsheng Zhao
Peking University Third Hospital

Corresponding Author:zhaorongsheng@bjmu.edu.cn

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Abstract

Thrombocytopenia can cause substantial morbidity and mortality in critically ill patients. There are multiple etiology factors and various mechanisms associated with thrombocytopenia, of which drug-induced thrombocytopenia (DITP) deserves attention. Herein, we describe a case of severe thrombocytopenia during intensive care unit (ICU) hospitalization that was probable to be associated with vancomycin. In addition, clinical studies evaluating thrombocytopenia caused by vancomycin were systematically reviewed and 6 studies with acceptable quality were included and analyzed. By revealing the process of identifying this case of DITP and reviewing relevant clinical studies, a risk alert of vancomycin related severe hematotoxicity should be focused on.