MATERIAL AND METHODS
A total of 318 patients who underwent RP with the diagnosis of prostate
adenocarcinoma in Izmir Katip Celebi University Ataturk Training and
Research Hospital between January 2009 and December 2017 were
retrospectively analyzed through the hospital system. Ethics committee
approval was obtained from the Non-Invasive Research Ethics Committee of
Izmir Katip Celebi University.
The age, gender, preoperative biopsy results, the operation date,
postoperative follow-up time, and the latest data regarding their
survival were taken from the hospital system and the National Death
Database. Preoperative and postoperative serum PSA values of the cases,
the time from surgery to recurrence in patients with recurrence in PSA
values, and treatment protocols applied to the patients were examined
and recorded.
All H&E stained slides prepared from the tissues fixed with 10%
formaldehyde solution and embedded in paraffin blocks were obtained from
the Pathology Clinic slide storage and re-evaluated according to the
Modified WHO-ISUP 2016 classification under the microscope. GSs of the
cases, GG categories, HP patterns, and the percentage of these patterns,
the presence of EPE, SMP, LVI, PNI, HDPIN, and tertiary patterns were
evaluated and recorded. According to AJCC TNM 8th edition, pathological
stages of the cases were classified as pT2, pT3a, and pT3b.
Thirty-three patients who did not come to the hospital for postoperative
follow-up and were not followed up for at least 3 months or did not have
two consecutive serum PSA values were excluded from the study.