Biochemical recurrence analysis
No significant relationship was found between the age of the patients and BCR, (p=0.974). The relationship between the preoperative PSA values and BCR status was significant (p<0.001). While the median preoperative PSA value was 10 (6.7-19.4) ng/ml in patients with BCR, it was found as 6.7 (IQR:5-9.89) ng/ml in patients without BCR.
In terms of HP evaluation and BCR status, a statistically significant correlation was found between the presence of EPE, SMP, PNI, LVI, SVI, and BCR (p<0.001). There was no statistically significant relationship between the presence of HGPIN and the presence of a high-grade tertiary pattern and BCR (p>0.05). In the subsequent multivariate analyzes, EPE, SMP, and SVI preserved their significance (p<0.001) (Table 4).
The tumor volume and BCR showed a statistically significant relationship (p<0.001). While the median tumor volume was 10% (IQR:6.7-19) in patients with BCR, it was 7% (IQR:4-12) in the others. Pattern 4 percentage and BCR also showed a significant relationship (p<0.001). While the median pattern 4 percentage was 45% (IQR:25-70) in patients with BCR, it was 18% (IQR:10-20) in the others. The rate of BCR increased significantly as the pathological stage increased (p<0.001).
In the univariate analyses according to HP patterns, the morphologies of fused glands, cribriform glands, cribriform glands with comedonecrosis, sheets/cords, solid areas, and single-cell infiltration was found to be statistically significant in terms of BCR (p<0.001). In the subsequent multivariant analyzes, the fused gland, cribriform gland, layers/cords, and solid area morphologies preserved their significance (p=0.043, p<0.001, p<0.001, p=0.001) (Table 3).