The Epithelial Barrier Hypothesis: a 20-year journey
Yagiz Pat1,2*, Ismail Ogulur1,3*
1 Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
2 Department of Medical Microbiology, Faculty of Medicine, Aydın Adnan Menderes University, Aydın, Turkey
3 Division of Pediatric Allergy and Immunology, School of Medicine, Marmara University, Istanbul, Turkey
*Corresponding authors:
Yagiz Pat, Swiss Institute of Allergy and Asthma Research (SIAF), Herman Burchard Str. 9, 7265 Davos Wolfgang, Switzerland, e-mail: yagizpat@gmail.com
Ismail Ogulur, Swiss Institute of Allergy and Asthma Research (SIAF), Herman Burchard Str. 9, 7265 Davos Wolfgang, Switzerland, e-mail: ismail.ogulur@gmail.com
Keywords: Epithelial barrier hypothesis, allergic diseases, autoimmune diseases, metabolic diseases, leaky gut, microbial dysbiosis, tissue microinflammation, type 1 immunity, type 2 immunity
Conflict of Interest: Dr Pat and Dr Ogulur have nothing to disclose.
Acknowledgement: We would like to thank Dr Anna Globinska for assistance in generating the graphical figure.