In 2010, the Iron Disorders Institute published the first seminal article on the underestimated risk of a homozygous HFE gene H63D mutation. This short but important article has lost none of its relevance. Since it is in danger of being forgotten and disappearing from more and more websites, we are publishing a reprint of the still seminal article, expanded with some new findings.

Vaccinated people think they are completely immune to Covid-19 and cannot infect others. This is a false assumption. In November 2020, Europe was on the brink of a triage situation. Now it's November again, a year later, and the situation has worsened despite vaccination campaigns. What went wrong?

Testing for microscopic blood traces, protein and other parameters by means of test strips has been a standard method in general medical and urological practices for years, but also in private settings. We report a potential source of error in the measurement of protein content of urine in men which has never been addressed in the manufacturer's instructions or in other publications.

As a conservative form of treatment for scoliosis and kyphosis (postural deficits), orthotic therapy still represents the gold standard of non-surgical orthopedics. In light of increasingly frequent complications due to dangerous wound infections caused by multi-resistant germs, it is to be expected that the treatment of clinically relevant postural deformities will again be increasingly conservative in the future. Apart from "saving" the patient from wearing an orthosis, surgical (invasive) treatment has not been proven to be superior.

Erectile dysfunction (ED) is what physicians call the inadequate or absent stiffening of the penis despite emotional sexual arousal. More and more men are suffering from such erectile issues. The better we understand the involvement of the central nervous system in various sexual functions, the more we will also understand its determining role in these disorders. Erectile dysfunction are an increasing health problem because of the aging of the population and new effects through readily available pornography (negative effects of chronic over-stimulation) which have an impact on young men.

In the case of a suspicious mole on the skin, the question always arises as to whether it is benign or malignant. Is it a harmless mole, a capillary malformation or a basal cell carcinoma, squamous cell carcinoma or even a melanoma? Often the nevus can be assessed just by a close examination of the lesion and a few questions about its origin. However, every dermatologist knows all too well the problem that very different lesions can look extremely similar to the naked eye and even on dermatoscopy. Therefore, the question arises: how should dermatology deal with and communicate in such cases? This article identifies ways forward in this difficult situation, which occurs tens of thousands of times a day around the globe.

Medicine has always reflected the behavior of its practitioners. It can look back on an impressive history with the Hippocratic Oath, which is approximately 2000 to 2500 years old. But despite this history, the question remains why there should be medical ethics or whether it is not sufficient to demand morally of a physician what is to be demanded of every citizen anyway. A paper by the “Ethics in Medicine Working Group“ of the International Association of Therapists & Medical Doctors (IAAT).

Ever since I co-founded the International H63D Research Consortium, I have always considered it my duty to pass on the most important knowledge about H63D syndrome to my colleagues in academia, research and applied medicine. Before I leave the consortium for a new career step, there are still some data to be published, which my current colleagues will certainly work on in more detail at a later stage. After all, knowledge can save lives and prevent suffering. I will publish these data in the following, because they speak for themselves.

In a study on the prevention of injury in patients with H63D syndrome and cataplexy, statistical analysis revealed an unexpected but clinically highly significant finding. Apparently, in this patient population, an inverse correlation exists between the severity of tic symptomatology on the one hand and narcolepsy with cataplexy on the other hand, as well as a parallel increase in the typical signs of degeneration observed in transcranial sonography of the substantia nigra. This finding has clinically far-reaching implications.

Patients suffering from H63D syndrome have a significant incidence of narcolepsy with cataplexy as a symptom. Previous studies have shown that the presence of narcolepsy with cataplexy in the context of H63D syndrome is a surrogate marker for structural brain damage. Now, the aim was to clarify which measures best protect affected patients with cataplexy from injury.

H63D syndrome is a serious and clinically progressive disorder of iron metabolism caused by non-transferrin-bound iron (NTBI). In 2019, after scientists from around the world joined together to form the H63D Syndrome Research Consortium (a non-profit entity), a consensus paper "H63D Syndrome" was adopted at a meeting in Oslo in December 2019. With this new paper, we summarize what the leading experts in the field know about the syndrome in 2021.

After reviewing the current literature and our systematically evaluated experience gained in daily practice, we propose a simplified action algorithm in case of nevi and other melanocytic skin lesions. Our approach is less stressful for the patients and, according to our conclusions, more economical, efficient and, above all, much safer than the recommendations currently in effect.