Bone marrow mesenchymal stem cells (BM-MSCs) are one of the most popular
cell types for tissue engineering and regenerative medicine. It is
generally believed that reduced oxygen tension plays a critical role in
the success of implantation and cell expansion. Here, based on evidence
from metabolic flux simulation of BM-MSCs, we suggest that although
oxygen availability can slightly improve cell proliferation, it is not
as important as glucose availability. Consequently, glucose-releasing
scaffolds might improve BM-MSC characteristics for clinical
applications. |