References
1. Ten threats to global health in 2019.
https://www.who.int/vietnam/news/feature-stories/detail/ten-threats-to-global-health-in-2019.
Accessed February 14, 2021.
2. Gerding DN, Larson TA. Aminoglycoside resistance in gram-negative
bacilli during increased amikacin use. Comparison of experience in 14
United States hospitals with experience in the Minneapolis Veterans
Administration Medical Center. Am J Med . 1985;79(1 SUPPL. 1):1-7.
doi:10.1016/0002-9343(85)90184-6
3. Gerding DN, Larson TA, Hughes RA, Weiler M, Shanholtzer C, Peterson
LR. Aminoglycoside resistance and aminoglycoside usage: ten years of
experience in one hospital. Antimicrob Agents Chemother .
1991;35(7):1284-1290. http://www.ncbi.nlm.nih.gov/pubmed/1929283.
Accessed March 15, 2017.
4. Bonhoeffer S, Lipsitch M, Levin BR, et al. Evaluating treatment
protocols to prevent antibiotic resistance. Proc Natl Acad Sci U S
A . 1997;94(22):12106-12111. doi:10.1073/PNAS.94.22.12106
5. Bergstrom CT, Lo M, Lipsitch M. Ecological theory suggests that
antimicrobial cycling will not reduce antimicrobial resistance in
hospitals. Proc Natl Acad Sci U S A . 2004;101(36):13285-13290.
doi:10.1073/pnas.0402298101
6. Levin BR, Bonten MJM. Cycling antibiotics may not be good for your
health. Proc Natl Acad Sci U S A . 2004;101(36):13101-13102.
doi:10.1073/pnas.0404970101
7. Brown EM, Nathwani D. Antibiotic cycling or rotation: a systematic
review of the evidence of efficacy. J Antimicrob Chemother .
2004;55(1):6-9. doi:10.1093/jac/dkh482
8. Abel zur Wiesch P, Kouyos R, Abel S, Viechtbauer W, Bonhoeffer S.
Cycling Empirical Antibiotic Therapy in Hospitals: Meta-Analysis and
Models. PLoS Pathog . 2014;10(6). doi:10.1371/journal.ppat.1004225
9. Chatzopoulou M, Reynolds L. Role of Antimicrobial Restrictions in
Bacterial Resistance Control: A Systematic Literature Review. J
Hosp Infect . September 2019. doi:10.1016/J.JHIN.2019.09.011
10. Chatzopoulou M, Kyriakaki A, Reynolds L. Review of antimicrobial
resistance control strategies: low impact of prospective audit with
feedback on bacterial antibiotic resistance within hospital settings.Infect Dis (Auckl) . December 2020:1-10.
doi:10.1080/23744235.2020.1846777
11. Dellit TH, Owens RC, McGowan JE, et al. Infectious Diseases Society
of America and the Society for Healthcare Epidemiology of America
Guidelines for Developing an Institutional Program to Enhance
Antimicrobial Stewardship. Clin Infect Dis . 2007;44(2):159-177.
doi:10.1086/510393
12. Center for Disease Prevention and Control. Core Elements of Hospital
Antibiotic Stewardship Programs | Get Smart for Healthcare
| CDC.
http://www.cdc.gov/getsmart/healthcare/implementation/core-elements.html.
13. Cadena J, Taboada CA, Burgess DS, et al. Antibiotic cycling to
decrease bacterial antibiotic resistance: a 5-year experience on a bone
marrow transplant unit. Bone Marrow Transplant .
2007;40(2):151-155. doi:10.1038/sj.bmt.1705704
14. Toltzis P, Dul MJ, Hoyen C, et al. The Effect of Antibiotic Rotation
on Colonization With Antibiotic-Resistant Bacilli in a Neonatal
Intensive Care Unit. Pediatrics . 2002;110(4):707-711.
doi:10.1542/peds.110.4.707
15. Raineri E, Crema L, Dal Zoppo S, et al. Rotation of antimicrobial
therapy in the intensive care unit: impact on incidence of
ventilator-associated pneumonia caused by antibiotic-resistant
Gram-negative bacteria. Eur J Clin Microbiol Infect Dis .
2010;29(8):1015-1024. doi:10.1007/s10096-010-0964-5
16. Cumpston A, Craig M, Hamadani M, Abraham J, Hobbs GR, Sarwari AR.
Extended follow-up of an antibiotic cycling program for the management
of febrile neutropenia in a hematologic malignancy and hematopoietic
cell transplantation unit. Transpl Infect Dis .
2013;15(2):142-149. doi:10.1111/tid.12035
17. Bennett KM, Scarborough JE, Sharpe M, et al. Implementation of
antibiotic rotation protocol improves antibiotic susceptibility profile
in a surgical intensive care unit. J Trauma - Inj Infect Crit
Care . 2007;63(2):307-311. doi:10.1097/TA.0b013e318120595e
18. Nijssen S, Fluit A, Van De Vijver D, Top J, Willems R, Bonten MJM.
Effects of reducing beta-lactam antibiotic pressure on intestinal
colonization of antibiotic-resistant gram-negative bacteria.Intensive Care Med . 2010;36(3):512-519.
doi:10.1007/s00134-009-1714-y
19. Smith RL, Evans HL, Chong TW, et al. Reduction in rates of
methicillin-resistant Staphylococcus aureus infection after introduction
of quarterly linezolid-vancomycin cycling in a surgical intensive care
unit. Surg Infect (Larchmt) . 2008;9(4):423-431.
doi:10.1089/sur.2007.024
20. Chong Y, Shimoda S, Yakushiji H, et al. Antibiotic Rotation for
Febrile Neutropenic Patients with Hematological Malignancies: Clinical
Significance of Antibiotic Heterogeneity. PLoS One . 2013;8(1).
doi:10.1371/journal.pone.0054190
21. Teranishi H, Koga Y, Nishio H, et al. Clinical efficacy of cycling
empirical antibiotic therapy for febrile neutropenia in pediatric cancer
patients. J Infect Chemother . 2017;23(7):463-467.
doi:10.1016/j.jiac.2017.03.020
22. Martínez J-A, Nicolás J-M, Marco F, et al. Comparison of
antimicrobial cycling and mixing strategies in two medical intensive
care units. Crit Care Med . 2006;34(2):329-336.
http://www.ncbi.nlm.nih.gov/pubmed/16424711. Accessed March 14, 2017.
23. van Duijn PJ, Verbrugghe W, Jorens PG, et al. The effects of
antibiotic cycling and mixing on antibiotic resistance in intensive care
units: a cluster-randomised crossover trial. Lancet Infect Dis .
2018;18(4):401-409. doi:10.1016/S1473-3099(18)30056-2
24. Jayashree M, Singhi S, Ray P, Gautam V, Ratol S, Bharti S.
Longitudinal comparative trial of antibiotic cycling and mixing on
emergence of gram negative bacterial resistance in a pediatric medical
intensive care unit. J Crit Care . 2020;56:243-248.
doi:10.1016/j.jcrc.2020.01.013
25. Ginn AN, Wiklendt AM, Gidding HF, et al. The ecology of antibiotic
use in the ICU: homogeneous prescribing of cefepime but not tazocin
selects for antibiotic resistant infection. PLoS One .
2012;7(6):e38719. doi:10.1371/journal.pone.0038719
26. van Loon HJ, Vriens MR, Fluit AC, et al. Antibiotic Rotation and
Development of Gram-Negative Antibiotic Resistance. Am J Respir
Crit Care Med . 2005;171(5):480-487. doi:10.1164/rccm.200401-070OC
27. Tsukayama DT, Loon HJ va., Cartwright C, et al. The evolution of
Pseudomonas aeruginosa during antibiotic rotation in a medical intensive
care unit: the RADAR-trial. Int J Antimicrob Agents .
2004;24(4):339-345. doi:10.1016/j.ijantimicag.2004.04.011
Figure 1: PRISMA chart depicting the study selection process
Table 1: Catalogue of the studies assessing the effects of antimicrobial
cycling on bacterial resistance rates; A p value<0.05 was
regarded as the statistical threshold of significance in all studies and
is accordingly recorded as such.