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\begin{document}

\title{Hypersensitivity Reactions to Biologicals: an EAACI position paper}



\author[1]{Sevim Bavbek}%
\author[2]{Mauro Pagani}%
\author[3]{Emilio Alvarez-Cuesta}%
\author[4]{Mariana Castells}%
\author[5]{Adile Berna Dursun}%
\author[6]{Sahar Hamadi}%
\author[7]{Ricardo Madrigal-Burgaleta}%
\author[8]{Soledad Sanchez-Sanchez}%
\author[9]{Alessandra Vultaggio}%
\affil[1]{Ankara University Faculty of Medicine}%
\affil[2]{ASST Mantova}%
\affil[3]{Hospital Ramón y Cajal}%
\affil[4]{Brigham and Women's Hospital}%
\affil[5]{Recep Tayyip Erdoğan University}%
\affil[6]{Division of Immunology and Allergy;  Department of Medicine, Brigham and Women’s Hospital}%
\affil[7]{St Bartholomew's Hospital, Barts Health NHS Trust}%
\affil[8]{ University Hospital Complex A Coruña (CHUAC),}%
\affil[9]{Azienda Ospedaliera Universitaria Careggi,  }%


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  \date{June 01, 2024}


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\begin{abstract}
Because of their selectivity, biologicals are crucial therapeutic agents
in oncological, immunological, and inflammatory diseases and their use
in clinical practice is broadening. Biologicals are among the most
common drugs that can cause hypersensitivity reactions (HSRs), and this
is primarily attributed to an explosion in new treatment options that
has developed through personalized and precision medicine. Patients can
develop HSRs to these agents during the first lifetime exposure or after
repeated exposure. Despite its relatively high prevalence, the
underlying mechanisms and optimal management of HSRs to biologicals
remain incompletely explained. In this position paper, the authors
provided evidence-based recommendations for the diagnosis and management
of HSRs to biologicals. Additionally, the document defines unmet needs,
which should be topics of future studies.%
\end{abstract}%



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