Figure 2:
Top panel: question 3a from the survey.
Bottom panel: bar chart of answers across 503 ‘non-clinical’ respondents and 285 ‘clinical’ ones. Respondents chose between the transcript that covers the most clinically relevant variants (D), that is most abundant (E), that has the longest coding sequence (C) or that is used historically.
The results favoured (D), the transcript that covers the most clinically relevant variants, or (E) the most abundant overall. However, for the clinical group, there was a strong preference for the transcript that covers the most clinically relevant variants (D) (64%) despite having lower abundance overall. In contrast, there was no obvious preference between these choices for the non-clinical group. Here neither the longest coding transcript (C), nor the historical transcript were popular preferences.