Figure 2:
Top panel: question 3a from the survey.
Bottom panel: bar chart of answers across 503 ‘non-clinical’ respondents
and 285 ‘clinical’ ones. Respondents chose between the transcript that
covers the most clinically relevant variants (D), that is most abundant
(E), that has the longest coding sequence (C) or that is used
historically.
The results favoured (D), the transcript that covers the most clinically
relevant variants, or (E) the most abundant overall. However, for the
clinical group, there was a strong preference for the transcript that
covers the most clinically relevant variants (D) (64%) despite having
lower abundance overall. In contrast, there was no obvious preference
between these choices for the non-clinical group. Here neither the
longest coding transcript (C), nor the historical transcript were
popular preferences.