Statistical Methods:
For comparison of IC50s, a Brown-Forsythe and Welch ANOVA with a post-hoc Games-Howell multiple comparison was performed with significance reported as * for p ≤ 0.05, ** for p ≤ 0.005, *** for p ≤ 0.0005, and **** for p ≤0.0001.
In MEA experiments, data were averaged from n individual MEA wells for each hiPSC line, with individual line data also shown. A repeated measures two-way ANOVA test was performed to determine statistical significance between drug treatments and over time, with significance reported as P ≤ 0.05.