Data Analysis:
Data analysis for the patch-clamp electrophysiology was performed using DataController384 V1.5.2 (Nanion Technologies) and Prism 8 (Graphpad Software, San Diego, CA, USA). Concentration response curves were fit with the Hill equation:
\begin{equation} \text{normalized\ }I_{\text{hERG}}\ inhibition=\frac{\left[\text{drug}\right]^{n}}{{\text{IC}_{50}}^{n}+{[drug]}^{n}}\nonumber \\ \end{equation}
where [drug] is the drug concentration, n is the Hill coefficient, and IC50 is the half-maximal inhibitory concentration.