Data Analysis:
Data analysis for the patch-clamp electrophysiology was performed using
DataController384 V1.5.2 (Nanion Technologies) and Prism 8 (Graphpad
Software, San Diego, CA, USA). Concentration response curves were fit
with the Hill equation:
\begin{equation}
\text{normalized\ }I_{\text{hERG}}\ inhibition=\frac{\left[\text{drug}\right]^{n}}{{\text{IC}_{50}}^{n}+{[drug]}^{n}}\nonumber \\
\end{equation}where [drug] is the drug concentration, n is the Hill
coefficient, and IC50 is the half-maximal
inhibitory concentration.