Statistical analysis
The Shapiro-Wilk test for normality was performed. Data were presented as means + s.e.m for parametric analyses and as medians + s.d. for nonparametric analyses, as indicated in the figure legends. Statistical analyses were performed using Prism 8 (GraphPad Software). For normally distributed data we performed ordinary one-way ANOVA or one-way repeated measures ANOVA with Tukey’s or Dunnetts’s post hoc tests, respectively, for multiple comparisons to determine differences between groups, or if not normally distributed the Kruskal-Wallis test followed by post hoc testing (if the Kruskal-Wallis was significant) using un-paired Mann-Whitney U tests was performed, as mentioned in the respective figure legends. Data were accepted as significantly different when P<0.05.