Authors Year Origin Study Design N Workup Pickup Rate Pickup Rate HPV Pickup rate HPV negative Recommendations
Vent et al27 2013 Germany RS 47 CT/MRI, FDG-PET< Skeletal scintigraphy. PE- if Ix negative BL tonsillectomy, Biopsy BOT, NP 39% (all workup) 9/20 where tumour found (HPV PCR and P16) P16 can serve to locate primary cancer in oropharynx. Positive prognostic indicator
Podeur et al19 2020 France RS 60 Negative Ex, CT, PETCT, endoscopy Tonsils 26% Tonsillar pickup 59% if HPV positive 0% pickup rate for HPV -ve Inc pickup rate OP HPV positive. Extended workup inc BL PT +/- TBM HPV positive
Saber et al24 2017 Denmark RS 1119 BL tonsillar cancer pts Only 1/12 HPV negative both tonsils BL PT - BL tonsillar tumours primarily HPV16+ and most often diagnosed as workup CUP