1.1
Tonsil BOT Nasopharynx Hypopharynx Piriform sinus/fossa Comment
Haas9
No random Biopsies of tonsils. TE BL 14% (6/53)
7.6% (4/53)
9.4% (5/53)
0% (0/53)
Systematic and blind. 4 of 57 were not true CUP
Tanzler5 13% (7/54) (39%TE 28/71) 18% (10/85) 0% (0/77) 0% (0/53) Random directed
Waltonen 200910
3.2% 3/95 (29.6% 8/27 PT) 6.3% (6/95) (7.4% 2/27 PT)
1.1% (1/95)
1.1% (1/95) (Further 3.7% 1/27 from PT not random Bx)
Mainly tonsils. Some BOT and hypopharynx found with PT
McQuone 199811
13% (2/15) TE 39% (9/23)
0% (0/34)
0% (0/34)
0% (0/34)
Tonsil mainly directed Bx
1.2 Tonsil BOT Nasopharynx Hypopharynx Piriform fossa Comment
Issing et al 20031
Overall: 4.2% 7/167 Bx: 2.9% (5/167) (TE 2/167) Overall primaries identified: 7/36 Overall 2.9% 5/167 Overall primaries identified: 5/36 Overall 2.4% (4/167) Overall primaries identified: 4/36 Overall 4.8% 8/167 Overall primaries identified: 8/36 Overall 3.6% (6/167) Overall primaries identified: 6/36 Overall Ix CUP 36 primaries found in 167 CUP’s
Lee et al 202012
Overall CUP 28.3% (51/180) Overall primaries identified: 51/92 (Tonsillectomy 28/87) Overall CUP 20.1% (37/180) Overall primaries identified: 37/92 (Lingual tonsillectomy 4/8) 0.6% 1/180 (not all had NP Bx Overall primaries identified: 1/92 Tonsils via tonsillectomy and deep biopsy 92 primaries found in 180 CUP’s
Waltonen 200913
Overall CUP 18.6% (34/183) Overall primaries identified: 34/84 Overall CUP 15.3% (28/183) Overall primaries identified: 28/84 Overall CUP 2.19% (4/183) Overall primaries identified: 4/84 Overall CUP 6% (11/183) Overall primaries identified: 11/84 Deep biopsy or tonsillectomy 84 primaries found in 183 CUP’s
Cianchetti 200914
Overall CUP 25% (59/236) Overall primaries identified: 59/126 (35/79 from PT) 24.6% (58/236) Overall primaries identified: 58/126 0.4% (1/236) Overall primaries identified: 1/126 4.2% (10/236) Overall primaries identified: 10/126 Not all true negative workup 126 total primaries found in 236 CUP. Not all neg workup
Ryan 201915
Overall CUP 23/110) Overall primaries identified: 23/59 38.9% (23/59) Overall CUP 28/110 Overall primaries identified: 28/59 47.5% (28/59) TOR Overall CUP 0/110 Overall primaries identified: 0% (0/59) Overall CUPl 1/110 Overall primaries identified: 1.7% (1/59) 59 primaries found in 110 CUP’s.. Some positive findings on workup. TORS OP 8.5% (5/59)
Nagel 201416
Overall 11/52 Overall primaries identified: 25.7% (11/39) Overall 26/52 Overall primaries identified: 66.7% (26/39) TLM Overall 1/52 Overall primaries identified: 2.6% (1/39) Overall 2/52 Overall primaries identified: 5.1% (2/39) TLM 39 primaries found in 52 CUP’s
Karni 201117
Overall 7/30 Overall primaries identified: (7/20) Overall 12/30 Overall primaries identified: 57.1% (12/20) TLM Overall 1/30 Overall primaries identified: 4.8% (1/20) Overall 1/30 Overall primaries identified: 4.8% (1/20) 20 primaries found in 30 CUP’s TLM Inc synchronous as diff sites