1.1 |
|
|
|
|
|
|
|
Tonsil |
BOT |
Nasopharynx |
Hypopharynx |
Piriform sinus/fossa |
Comment |
Haas9
|
No random Biopsies of tonsils.
TE BL
14% (6/53)
|
7.6% (4/53)
|
9.4% (5/53)
|
|
0% (0/53)
|
Systematic and blind. 4 of 57 were not true CUP
|
Tanzler5
|
13% (7/54) (39%TE 28/71) |
18% (10/85) |
0% (0/77) |
|
0% (0/53) |
Random directed |
Waltonen 200910
|
3.2% 3/95
(29.6% 8/27 PT)
|
6.3% (6/95)
(7.4% 2/27 PT)
|
1.1% (1/95)
|
1.1% (1/95)
(Further 3.7% 1/27 from PT not random Bx)
|
|
Mainly tonsils. Some BOT and hypopharynx found with PT
|
McQuone 199811
|
13% (2/15)
TE 39% (9/23)
|
0% (0/34)
|
0% (0/34)
|
|
0% (0/34)
|
Tonsil mainly directed Bx
|
1.2 |
Tonsil |
BOT |
Nasopharynx |
Hypopharynx |
Piriform fossa |
Comment |
Issing et al 20031
|
Overall: 4.2% 7/167
Bx: 2.9% (5/167) (TE 2/167)
Overall primaries identified:
7/36
|
Overall 2.9% 5/167
Overall primaries identified:
5/36
|
Overall 2.4% (4/167)
Overall primaries identified:
4/36
|
Overall 4.8% 8/167
Overall primaries identified:
8/36
|
Overall 3.6% (6/167)
Overall primaries identified:
6/36
|
Overall Ix CUP
36 primaries found in 167 CUP’s
|
Lee et al 202012
|
Overall CUP 28.3% (51/180)
Overall primaries identified:
51/92
(Tonsillectomy 28/87)
|
Overall CUP 20.1% (37/180)
Overall primaries identified:
37/92
(Lingual tonsillectomy 4/8)
|
0.6% 1/180
(not all had NP Bx
Overall primaries identified:
1/92
|
|
|
Tonsils via tonsillectomy and deep biopsy
92 primaries found in 180 CUP’s
|
Waltonen 200913
|
Overall CUP 18.6% (34/183)
Overall primaries identified:
34/84
|
Overall CUP 15.3% (28/183)
Overall primaries identified:
28/84
|
Overall CUP 2.19% (4/183)
Overall primaries identified:
4/84
|
Overall CUP 6% (11/183)
Overall primaries identified:
11/84
|
|
Deep biopsy or tonsillectomy
84 primaries found in 183 CUP’s
|
Cianchetti 200914
|
Overall CUP 25% (59/236)
Overall primaries identified:
59/126
(35/79 from PT)
|
24.6% (58/236)
Overall primaries identified:
58/126
|
0.4% (1/236)
Overall primaries identified:
1/126
|
|
4.2% (10/236)
Overall primaries identified:
10/126
|
Not all true negative workup
126 total primaries found in 236 CUP.
Not all neg workup
|
Ryan 201915
|
Overall CUP 23/110)
Overall primaries identified:
23/59
38.9% (23/59)
|
Overall CUP 28/110
Overall primaries identified:
28/59
47.5% (28/59)
TOR
|
Overall CUP
0/110
Overall primaries identified:
0% (0/59)
|
Overall CUPl 1/110
Overall primaries identified:
1.7% (1/59)
|
|
59 primaries found in 110 CUP’s.. Some positive findings on workup.
TORS
OP 8.5% (5/59)
|
Nagel 201416
|
Overall 11/52
Overall primaries identified:
25.7% (11/39)
|
Overall 26/52
Overall primaries identified:
66.7% (26/39)
TLM
|
Overall 1/52
Overall primaries identified:
2.6% (1/39)
|
Overall 2/52
Overall primaries identified:
5.1% (2/39)
|
|
TLM
39 primaries found in 52 CUP’s
|
Karni 201117
|
Overall 7/30
Overall primaries identified:
(7/20)
|
Overall 12/30
Overall primaries identified:
57.1% (12/20)
TLM
|
Overall 1/30
Overall primaries identified:
4.8% (1/20)
|
Overall 1/30
Overall primaries identified:
4.8% (1/20)
|
|
20 primaries found in 30 CUP’s
TLM
Inc synchronous as diff sites
|