Authors |
Year |
Origin |
Study Design |
N |
Workup |
Pickup Rate |
Pickup Rate HPV |
Pickup rate HPV negative |
Recommendations |
Vent et al27
|
2013 |
Germany |
RS |
47 |
CT/MRI,
FDG-PET< Skeletal scintigraphy. PE- if Ix negative BL
tonsillectomy, Biopsy BOT, NP |
39% (all workup) |
|
9/20 where tumour
found (HPV PCR and P16) |
P16 can serve to locate primary cancer in
oropharynx. Positive prognostic indicator |
Podeur et al19
|
2020 |
France |
RS |
60 |
Negative
Ex, CT, PETCT, endoscopy |
Tonsils 26% |
Tonsillar pickup 59% if HPV
positive |
0% pickup rate for HPV -ve |
Inc pickup rate OP HPV
positive. Extended workup inc BL PT +/- TBM HPV positive |
Saber et al24
|
2017 |
Denmark |
RS |
1119 |
BL
tonsillar cancer pts |
|
|
Only 1/12 HPV negative both tonsils |
BL PT -
BL tonsillar tumours primarily HPV16+ and most often diagnosed as workup
CUP |