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\begin{document}

\title{Is Magnesium Sulfate Treatment Really Effective in Moderate to Severe
Bronchiolitis?}



\author[1]{İlknur Bodur}%
\author[2]{Ayla  Akca Caglar}%
\author[3]{Aysun Tekeli}%
\author[4]{Ali Güngör}%
\author[1]{Muhammed Mustafa Güneylioglu}%
\author[1]{Betül Ozturk}%
\author[1]{Raziye Merve Yaradılmıs}%
\author[1]{Aytac Goktug}%
\author[1]{Can Demir Karacan}%
\author[1]{Nilden Tuygun}%
\affil[1]{SBU Ankara  Dr Sami Ulus Maternity Child Health and Diseases Training and Research Hospital}%
\affil[2]{Ankara City Hospital}%
\affil[3]{Ankara Gülhane Eğitim ve Araştırma Hastanesi}%
\affil[4]{Dr Sami Ulus Gynecology Obstetrics and Child Health and Diseases Training and Research Hospital}%


\vspace{-1em}



  
  \date{June 18, 2024}


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\selectlanguage{english}
\begin{abstract}
Objectives: The aim of our study is to examine the efficacy and safety
of intravenous magnesium sulfate in moderate-severe acute bronchiolitis.
Working hypothesis: Intravenous magnesium sulfate treatment may be
effective in the treatment of patients with bronchiolitis . Study
design: Retrospective, single-center cohort study Methodology: We
conducted a study in 150 infants presenting with moderate to severe
acute bronchiolitis. A total of 150 infants aged 1 month to 2 years who
presented with acute bronchiolitis to our pediatric emergency department
between January 2018 and March 2019 were admitted into the study. The
demographic characteristics, clinical score, and management of the
patients were examined. Results: A total of 150 infants were analyzed:
62 in the magnesium sulfate group (Group I) and 88 in the supportive
care group (Group II). Baseline clinical characteristics were similar in
both groups. Length of hospitalization was significantly shorter in
Group II. Clinical severity scores were also lower significantly earlier
in Group I (p=0.031, p=0.008, respectively at first and fourth hour).
Conclusions: Intravenous magnesium treatment in moderateto severe acute
bronchiolitis does not appear to conferany significant decrease in
clinical severity scores when compared to only supportive care%
\end{abstract}%



\sloppy


\selectlanguage{polish}\textbf{TİTLE PAGE}\selectlanguage{english}

\textbf{Is Magnesium Sulfate Treatment Really Effective in Moderate to
Severe Bronchiolitis?}

\textbf{Running Title:} Magnesium Sulfate Treatment

\selectlanguage{polish}İ\selectlanguage{english}lknur Bodur\textsuperscript{1}, Ayla Akca \selectlanguage{ngerman}Ça\selectlanguage{polish}ğ\selectlanguage{english}lar\textsuperscript{2},
Aysun Tekeli\textsuperscript{3}, Ali G\selectlanguage{ngerman}üngör\textsuperscript{1}, Muhammed
Mustafa Güneylio\selectlanguage{polish}ğ\selectlanguage{english}lu\textsuperscript{1}, Bet\selectlanguage{ngerman}ül Öztürk\textsuperscript{1},
Raziye Merve Yarad\selectlanguage{polish}ı\selectlanguage{english}lm\selectlanguage{polish}ış\selectlanguage{english}\textsuperscript{1}, Ayta\selectlanguage{ngerman}ç
Göktu\selectlanguage{polish}ğ\selectlanguage{english}\textsuperscript{1}, Can Demir Karacan\textsuperscript{1}, Nilden
Tuygun\textsuperscript{1}

\textsuperscript{1} MD. Department of Pediatric Emergency Medicine, Dr.
Sami Ulus Maternity and Child Health and Diseases Training and Research
Hospital, Ankara, Turkey

\textsuperscript{2} MD. Department of Pediatric Emergency Medicine,
Ministry of Health Ankara City Hospital, Ankara, Turkey

\textsuperscript{3} MD Department of Pediatric Emergency Medicine,
G\selectlanguage{ngerman}ülhane Training and Research Hospital, Ankara, Turkey

\textbf{Authors' e-mail addresses}

\selectlanguage{polish}İ\selectlanguage{english}lknur Bodur: ilknur.bodur1977@hotmail.com

Ayla Ak\selectlanguage{ngerman}ça Ça\selectlanguage{polish}ğ\selectlanguage{english}lar: dr.aylaakca@hotmail.com

Aysun Tekeli: aysunnakay@yahoo.com.tr

Ali G\selectlanguage{ngerman}üngör: gungorali19@gmail.com

Muhammed Mustafa Güneylio\selectlanguage{polish}ğ\selectlanguage{english}lu: drguneylioglu@gmail.com

Bet\selectlanguage{ngerman}ül Öztürk: drbetulozaydinozturk@gmail.com

Raziye Merve Yarad\selectlanguage{polish}ı\selectlanguage{english}lm\selectlanguage{polish}ış: \selectlanguage{english}karaomermerve@hotmail.com

Ayta\selectlanguage{ngerman}ç Göktu\selectlanguage{polish}ğ: \selectlanguage{english}aytacyaylaci@yahoo.com

Can Demir Karacan: candecan@hotmail.com

Nilden Tuygun: nildentuygun@gmail.com

\textbf{Corresponding author:~}

Dr. \selectlanguage{polish}İ\selectlanguage{english}lknur Bodur

Department of Pediatric Emergency Medicine, Dr. Sami Ulus Maternity and
Child Health and Diseases Training and Research Hospital, Ankara, Turkey

Email\emph{:}ilknur.bodur1977@hotmail.com

Phone number: 0505 240 56 61

Number of words (Manuscript): 1826

Number of words (Abstract): 190

Number of Tables: 2

Number of Figures: 3

Number of References: 24

Key words: Bronchiolitis; Infant; Magnesium sulfate

\textbf{Author Contribution}

MD Bodur, and Prof Tuygun and Karacan conceptualized and designed the
study, drafted the initial manuscript, and reviewed and revised the
manuscript.

Drs G\selectlanguage{ngerman}üngör, Öztürk, Güneylio\selectlanguage{polish}ğ\selectlanguage{english}lu and Yarad\selectlanguage{polish}ı\selectlanguage{english}lm\selectlanguage{polish}ış \selectlanguage{english}designed the data
collection instruments, collected data,

Dr Akca \selectlanguage{ngerman}Ça\selectlanguage{polish}ğ\selectlanguage{english}lar, Tekeli, G\selectlanguage{ngerman}öktu\selectlanguage{polish}ğ \selectlanguage{english}carried out the initial analyses, and
reviewed and revised the manuscript

We confirm that this work is original and has not been published
elsewhere, nor is it currently under consideration for publication
elsewhere.

We have no conflicts of interest to disclose.

All authors accept the copyright of the journal.

This paper was approved by the ethics committee.

\textbf{Sources of funding:} None

\selectlanguage{english}
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