METHODS
In this retrospective study, 233 KTRs were included in the study in our out-patient clinic for routine control within 12 months. KTRs according to uric acid level; uric acid> 7 mg / dL for men and> 6mg / dl for women were considered to be high SUA (n: 113). Allopurinol treatment was started at post-transplant >3.Month-<12. month. The remaining 120 patients had normal SUA levels. Fiftyseven KTRs with high SUA levels received allopurinol treatment and 56 patients did not. There were 118 patients who were followed for more than 5 years and they were evaluated separately. Of these, 56 had high SUA levels and 62 were normal. Of the 56 patients with high SUA level, 26 received allopurinol treatment and 30 did not (Table 1). Allopurinol group received 150 mg allopurinol treatment every other day. Patients also received triple immunosuppressive therapy (CNI + MMF or mTOR inhibitor and prednisolone) as standard therapy. In addition, they continued to antihypertensive drugs as needed.
Exclusion criterias: Patients with acute renal insufficiency, clinically overt heart failure, hepatic insufficiency, uncontrolled blood pressure (> 140 / 90mm / Hg) and diuretic therapy.
Age, sex, transplant date and laboratory results including serum uric acid, BUN, creatinine, sodium, potassium, chlorine, calcium, total protein, albumin, blood counts and drug levels were provided retrospectively from medical records. Visits were shown as 1. Baseline, 2. 6. Month, 3. 1. Year, 4: 2. year, 5. 5. year. Glomerular filtration rate (GFR) was measured using CKD-epi. Permanent reduction of GFR to 10 ml/min was considered as graft loss.
For statistical analysis SPSS 20.0 windows package program was used and p value <0.05 was considered significant. Frequency analysis, chi-square test, t-test and correlation analysis were used. To evaluate the change in the measurements obtained in the time interval, The Repeated Measurements Analysis was applied.

Ethical considerations

Written approval from the Ethics Board of Cukurova University Faculty of Medicine was obtained for the study.