| Control group | Control group | Control group | Intervention group | Intervention group | Intervention group | |
| Outcome | Baseline (n=40) | Follow-up (n=35) | P-value | Baseline (n=41) | Follow-up (n=36) | P-value |
| Efficacy† n (%) | 11 (27.5%) | 17 (48.6%) | <0.05* | 13 (31.7%) | 23 (63.9%) | <0.001** |
| Safety‡ Mean (SD) | 21.42 (12.16) | 23.73 (13.24) | <0.001** | 21.08 (10.59) | 18.91 (9.44) | <0.001** |
| Adherence§ Mean (SD) | 6.05 (1.26) | 5.85 (1.43) | >0.05 | 6.04 (1.09) | 7.61 (0.9) | <0.001** |
| Satisfaction¶ Mean (SD) | 2.2 (2.76) | 2.66 (2.68) | <0.05* | 0.76 (1.4) | 12.58 (1.4) | <0.0001** |
| QoL Mean (SD) | 70.88 (20.7) | 64.63 (21.58) | <0.05* | 70.75 (14.5) | 75.09 (14.87) | <0.001** |
| Difference between groups at follow-up | Difference between groups at follow-up | Difference between groups at follow-up | Difference between groups at follow-up | Difference between groups at follow-up | Difference between groups at follow-up | Difference between groups at follow-up |
| Outcome | Control group | Control group | Control group | Intervention group | Intervention group | P-value |
| Efficacy† | 17 (48.6%) | 17 (48.6%) | 17 (48.6%) | 23 (63.9%) | 23 (63.9%) | >0.05 |
| Safety‡ | 23.73 (13.24) | 23.73 (13.24) | 23.73 (13.24) | 18.91 (9.44) | 18.91 (9.44) | >0.05 |
| Adherence§ | 5.85 (1.43) | 5.85 (1.43) | 5.85 (1.43) | 7.61 (0.9) | 7.61 (0.9) | <0.0001** |
| satisfaction¶ | 2.66 (2.68) | 2.66 (2.68) | 2.66 (2.68) | 12.58 (1.4) | 12.58 (1.4) | <0.0001** |
| QoL | 64.63 (21.58) | 64.63 (21.58) | 64.63 (21.58) | 75.09 (14.87) | 75.09 (14.87) | <0.05* |