Abbreviations
VEGF, vascular endothelial growth factor A; qRT-PCR, quantitative
real-time PCR; NGST, next-generation sequencing technologies; 2D-DIGE,
two-dimensional fluorescence difference gel electrophoresis; iTRAQ,
Isobaric
tag for relative and absolute quantitation; TMT, Tandem Mass Tags; MS,
mass spectrometry; KEGG, Kyoto Encyclopedia of Genes and Genomes; DEG,
differentially expressed genes; DEMI, differentially expressed miRNAs;
DEP, differentially expressed proteins; VIP, variable importance in
projection; DEM, differentially expressed metabolites; LC-ESI-MS/MS,
liquid chromatography-electrospray ionization-tandem mass spectrometry;
DCM, Dilated cardiomyopathy (DCM); HCM, Hypertrophic cardiomyopathy
(HCM); PLS-DA , Partial least-squares-discriminant analysis; PHD2, egl
nine homolog 1; PHD3, egl nine homolog 3; FIH-1, Hypoxia-inducible
factor 1-alpha inhibitor; KDR1, vascular endothelial growth factor
receptor kdr; ANGPTL4, angiopoietin-related protein 4; NOS2, nitric
oxide synthase, inducible; ECE1, endothelin-converting enzyme 1; ALAS2,
5-aminolevulinate synthase, erythroid-specific, mitochondrial; HRG-1A,
heme transporter hrg1-A; urod, uroporphyrinogen decarboxylase; Blvra,
Biliverdin reductase A; UGT2A1; UDP-glucuronosyltransferase 2A1; PPOX,
protoporphyrinogen oxidase; HMOX2, Heme oxygenase 2; TF, transferrin;
TFRC, transferrin receptor protein 1; CA, carbonic anhydrase; HBα/β,
Hemoglobin subunit alpha/beta; GLUT1, Solute carrier family 2,
facilitated glucose transporter member 1; PK, pyruvate kinase; HK,
hexokinase; PFK1, 6-phosphofructokinase; LDH, L-lactate dehydrogenase;
PDK, pyruvate dehydrogenase kinase isoform 1; PDHA, Pyruvate
dehydrogenase; CS, Citrate synthase, mitochondrial; IDH, Isocitrate
dehydrogenase [NADP], mitochondrial; DLD, Dihydrolipoyl
dehydrogenase, mitochondrial; OGDH, 2-oxoglutarate dehydrogenase,
mitochondrial; sdha/b, Succinate dehydrogenase [ubiquinone]
flavoprotein/iron-sulfur subunit, mitochondrial; MDH1, Malate
dehydrogenase, cytoplasmic; PPRC1, peroxisome proliferator-activated
receptor gamma coactivator-related protein 1; GFM1, elongation factor G,
mitochondrial; LONP1, lon protease homolog, mitochondrial; SERAC1,
protein SERAC1; COX, cytochrome c oxidase; Mt-Cyb, Cytochrome b;
UQCRC1/2, Cytochrome b-c1 complex subunit 1/2, mitochondrial; CYC1,
Cytochrome c1, heme protein, mitochondrial; Cyb561a3, Cytochrome b
ascorbate-dependent protein 3; ATP5A1/B, ATP synthase subunit
alpha/beta, mitochondrial; Mn-SOD, manganese superoxide dismutase;
GSTM/T3, Glutathione S-transferase Mu 3/theta-3; NLRC3, NLR family CARD
domain-containing protein 3; NLRP3/P12, NACHT, LRR and PYD
domains-containing protein 3/12; IL-1β, Interleukin-1 beta; IFNGR1,
interferon gamma receptor 1; IKBKG, NF-kappa-B essential modulator;
NFKBIB, NF-kappa-B inhibitor beta; CHUK, inhibitor of nuclear factor
kappa-B kinase subunit alpha; MAPKAPK5, MAP kinase-activated protein
kinase 5; Map4k2, mitogen-activated protein kinase kinase kinase kinase
2; Map2k4, dual specificity mitogen-activated protein kinase kinase 4;
CDK, Cyclin-dependent kinase CCNI, Cyclin-I; YWHAZ, 14-3-3 protein
zeta/delta; MCM4/7, DNA replication licensing factor MCM4/7; CCNG2,
Cyclin-G2; DIDO1, death-inducer obliterator 1; MDC1, mediator of DNA
damage checkpoint protein 1; CDKN1B, cyclin-dependent kinase inhibitor
1B; GADD45A, growth arrest and DNA damage-inducible protein GADD45
alpha; PPARα/β, Peroxisome proliferator-activated receptor alpha/delta;
C-fos, Proto-oncogene c-Fos; HMGB1/3, High mobility group protein B1/3;
FAS, tumor necrosis factor receptor superfamily member 6; TNFR1, tumor
necrosis factor receptor superfamily member 1A; TNFRSF10B, tumor
necrosis factor receptor superfamily member 10B; FADD, FAS-associated
death domain protein; Casp3/8, caspase-3/8; HSP60, 60 kDa heat shock
protein, mitochondrial; BAD, bcl2-associated agonist of cell death;
HSC70, heat shock cognate 70 kDa protein; BAX, apoptosis regulator BAX;
BNIP1/2/3L, BCL2/adenovirus E1B 19 kDa protein-interacting protein
1/2/3-like; BCL2, apoptosis regulator Bcl-2; DIABLO, diablo homolog,
mitochondrial; ATP2A1, Sarcoplasmic/endoplasmic reticulum calcium ATPase
1; ATP2B4, plasma membrane calcium-transporting ATPase 4; GRP78, 78 kDa
glucose-regulated protein; PPP1R15A, protein phosphatase 1 regulatory
subunit 15B; NFE2L1, nuclear factor erythroid 2-related factor 1; DDIT3,
DNA damage-inducible transcript 3 protein