Infective endocarditis (IE) still has a high risk of mortality and morbidity, despite of developments in medical treatment. Intracranial hemorrhage is one of serious complication, which has poor outcome. We present a 30-year-old male with diagnosis of IE. He had severe aortic regurgitation and oscillating vegetations on both side of the aortic valve. Although there was no neurological symptom in preoperative period, cranial magnetic resonance imaging (MRI) revealed millimetric size ischemic lesions at the right cerebral hemisphere. We performed Ozaki procedure. However, cerebral hemorrhage occurred on the first postoperative day. Computerized tomography (CT) revealed hematoma in parietal and occipital lobes. He was treated with conservative anti-edema therapy and discharged from the hospital on the 25th day with minor visual defect of his eye. Echocardiography control revealed mild aortic regurgitation without any other pathologic finding after 18 months. Aortic neocuspidization by using using of glutaraldehyde treated autologous pericardium decreases the risk of fibrosis and calcification, and thrombosis events. Possibility of suspending the anticoagulant and antiplatelet regimen is a significant advantage in this type of repair. Ozaki procedure might be the first-choice surgical reconstruction technique in anatomically suitable IE cases.