Conclusions
This comprehensive meta-analysis of non-adherence to anti-diabetic
medications documented a higher proportion of medication non-adherence
among individuals with diabetes in LMIC settings when MMAS-8 item scale
was used and low when MMAS-4 and the 80-90% cut-off scales were used.
Various factors, such as disease factors, therapy-related factors,
healthcare system factor, patient-centered factors, and socio-economic
factors contributed to non-adherence. Therefore, multifaceted
intervention is needed to create supportive environment for individuals
to combat medication non-adherence. Furthermore, given that diabetes is
easily controlled by adherence to medication, it is essential to provide
trainings and interventional programmes to increase adherence rates in
affected individuals.