Figure 5
Proposed mechanism illustrating the intersection between glucose
metabolism and the HIF-1α pathway. At the transition from anaerobic to
mixed anaerobic-aerobic metabolism, intracellular lactate concentration
is maximal. In the presence of oxygen, the accumulation of lactate
stabilizes the transcription factor HIF-1α (hypoxia inducible factor 1α)
by interfering with proline-hydroxylase-2 (PHD2), resulting in the
regulation of hypoxia-induced gene expression independent of hypoxia
(pseudo-hypoxia).