Intracranial hypertension and radiculopathy in Neurobrucellosis: A case report

We report the clinical, imaging, echocardiography and muscle biopsy findings of a patient presenting by characteristics which have not been reported in previous Melas cases. This is the first reported case of MELAS accompanying with PFO, and the first case of MELAS with the progressive pattern of ischemic lesions.

The reported case is a 53-year-old woman with the history of long-standing rheumatoid arthritis who first presented with acute-onset dizziness and gait disturbance, periventricular linear and radial enhancement pattern on MRI and normal CSF analysis, successfully treated with an increase in the dose of oral steroids.

Anti-glutamic acid decarboxylase(Anti-GAD) are associated with various neurologic condition; but, no meningitis has been reported with it, so far. Evidence demonstrates the associated of autoimmune meningoencephalitis with Covid-19 infection. Here we report a 44-year-old female with progressive loss of consciousness with anti-GAD65 meningoencephalitis after Covid-19 infection.

Aceruloplasminemia is an autosomal recessive disease, caused by systemic iron accumulation due to mutations in the Ceruloplasmin gene. We report two Iranian siblings who have diagnosed with aceruloplasminemia. Based on our researches, dementia hasn't been published as the first neurological feature while one of them was presented with pure dementia

After performing DBS surgery on a patient with Tourette syndrome, significant improvement was observed in OCD, but the tic remained unchanged, which contradicts previous studies. Herein we discuss that fluctuations in the therapeutic outcomes may be due to differences in physiological conditions tic- or OCD-specified pathways.

Abstract Concurrent presentation of MS and congenital ichthyosis is extremely rare. In this study we present a case of a 27-year-old woman with congenital ichthyosis who presented with signs of multiple sclerosis. This concurrence may provide insight into any common immunopathologic and genetic mechanisms.

Rituximab use in multiple sclerosis has been promising. Cytokine release syndrome (CRS) is a common side effect of rituximab in patients with lymphoma. We report a case of a 44-year-old man with a history of relapsing-remitting multiple sclerosis, who presented with signs and symptoms consistent with CRS after rituximab initiation.