Intracranial hypertension and radiculopathy in Neurobrucellosis: A case report

We report the clinical, imaging, echocardiography and muscle biopsy findings of a patient presenting by characteristics which have not been reported in previous Melas cases. This is the first reported case of MELAS accompanying with PFO, and the first case of MELAS with the progressive pattern of ischemic lesions.

The reported case is a 53-year-old woman with the history of long-standing rheumatoid arthritis who first presented with acute-onset dizziness and gait disturbance, periventricular linear and radial enhancement pattern on MRI and normal CSF analysis, successfully treated with an increase in the dose of oral steroids.

Anti-glutamic acid decarboxylase(Anti-GAD) are associated with various neurologic condition; but, no meningitis has been reported with it, so far. Evidence demonstrates the associated of autoimmune meningoencephalitis with Covid-19 infection. Here we report a 44-year-old female with progressive loss of consciousness with anti-GAD65 meningoencephalitis after Covid-19 infection.

Will the people with demyelinating diseases ever be able to use CAR Treg cells to be cured, if it proves effective in the future? Probably not, considering its gigantic price. Researchers should focus on developing an affordable safe Treg-specific viral vector to produce CAR Treg’s in-vivo.  

Abstract Concurrent presentation of MS and congenital ichthyosis is extremely rare. In this study we present a case of a 27-year-old woman with congenital ichthyosis who presented with signs of multiple sclerosis. This concurrence may provide insight into any common immunopathologic and genetic mechanisms.

Rituximab use in multiple sclerosis has been promising. Cytokine release syndrome (CRS) is a common side effect of rituximab in patients with lymphoma. We report a case of a 44-year-old man with a history of relapsing-remitting multiple sclerosis, who presented with signs and symptoms consistent with CRS after rituximab initiation.