A 61 years old male had minimally symptomatic SARS-CoV-2 infection while taking everolimus. He remained RT-PCR positive for viral RNA for 52 days. Pegylated interferon for 4 weeks led to viral RNA clearance. The observations support consideration and further evaluation of combination therapy with everolimus plus interferon for COVID-19.

An 83 year old female had asymptomatic SARS-CoV-2 infection while taking ruxolitinib. She remained RT-PCR positive for viral RNA for >120 days, Pegylated interferon for 4 weeks led to viral RNA clearance. The observations support combination therapy of ruxolitinib + interferon for COVID-19.