|
t1/2 (h)
|
tmax (h)
|
Vd (L/ng)
|
CL
(mL/h*ng)
|
Cmax (ng/mL)
|
AUC(0→96)
(h*ng/mL)
|
BUP PK |
|
|
|
|
|
|
Feeding CYP2B6*1/*1 (n=11) |
15.95±5.68 |
2.91±1.41 |
4.310±2.165 |
185.16±39.62 |
98.92±22.62 |
828.97±179.94 |
Feeding CYP2B6 mutants (n=13) |
14.69±3.94 |
3.54±1.23 |
3.906±0.803 |
190.34±42.87 |
90.05±21.95 |
807.16±153.53 |
P |
0.529 |
0.256 |
0.538 |
0.763 |
0.341 |
0.752 |
HBUP PK |
|
|
|
|
|
|
Feeding CYP2B6*1/*1 (n=11) |
21.89±3.54 |
6.86±2.61 |
0.601±0.105 |
19.30±3.72 |
180.82±38.68 |
7555.68±1399.58 |
Feeding CYP2B6 mutants (n=13) |
22.14±3.84 |
6.46±2.29 |
0.889±0.525 |
29.45±20.78 |
165.57±105.56 |
7129.85±4389.42 |
P |
0.870 |
0.692 |
0.087 |
0.434 |
0.155 |
0.311 |