|
t1/2 (h)
|
tmax (h)
|
Vd (L/ng)
|
CL
(mL/h*ng)
|
Cmax (ng/mL)
|
AUC(0→96)
(h*ng/mL)
|
BUP PK |
|
|
|
|
|
|
Fasting CYP2B6*1/*1 (n=10) |
11.51±3.69 |
2.40±0.97 |
3.501±0.752 |
219.46±54.05 |
74.58±19.65 |
716.99±182.70 |
Feeding CYP2B6*1/*1 (n=11) |
15.95±5.68 |
2.91±1.41 |
4.310±2.165 |
185.16±39.62 |
98.92±22.62 |
828.97±179.94 |
P |
0.049*
|
0.352 |
0.277 |
0.111 |
0.017*
|
0.174 |
HBUP PK |
|
|
|
|
|
|
Fasting CYP2B6*1/*1 (n=10) |
19.75±3.79 |
6.30±1.70 |
0.830±0.140 |
30.64±10.08 |
125.64±24.74 |
5081.26±1479.82 |
Feeding CYP2B6*1/*1 (n=11) |
21.89±3.54 |
6.86±2.61 |
0.601±0.105 |
19.30±3.72 |
180.82±38.68 |
7555.68±1399.58 |
P |
0.197 |
0.773 |
0.000*
|
0.002*
|
0.001*
|
0.001*
|