t1/2 (h) tmax (h) Vd (L/ng) CL (mL/h*ng) Cmax (ng/mL) AUC(0→96) (h*ng/mL)
BUP PK
Fasting CYP2B6*1/*1 (n=10) 11.51±3.69 2.40±0.97 3.501±0.752 219.46±54.05 74.58±19.65 716.99±182.70
Feeding CYP2B6*1/*1 (n=11) 15.95±5.68 2.91±1.41 4.310±2.165 185.16±39.62 98.92±22.62 828.97±179.94
P 0.049* 0.352 0.277 0.111 0.017* 0.174
HBUP PK
Fasting CYP2B6*1/*1 (n=10) 19.75±3.79 6.30±1.70 0.830±0.140 30.64±10.08 125.64±24.74 5081.26±1479.82
Feeding CYP2B6*1/*1 (n=11) 21.89±3.54 6.86±2.61 0.601±0.105 19.30±3.72 180.82±38.68 7555.68±1399.58
P 0.197 0.773 0.000* 0.002* 0.001* 0.001*