t1/2 (h) tmax (h) Vd (L/ng) CL (mL/h*ng) Cmax (ng/mL) AUC(0→96) (h*ng/mL)
BUP PK
Fasting CYP2B6*1/*1 (n=10) 11.51±3.69 2.40±0.97 3.501±0.752 219.46±54.05 74.58±19.65 716.99±182.70
Fasting CYP2B6 mutants (n=10) 14.64±4.18 2.20±0.63 4.254±1.035 208.79±55.99 84.92±18.26 744.48±159.49
P 0.093 0.591 0.079 0.670 0.239 0.724
HBUP PK
Fasting CYP2B6*1/*1 (n=10) 19.75±3.79 6.30±1.70 0.830±0.140 30.64±10.08 125.64±24.74 5081.26±1479.82
Fasting CYP2B6 mutants (n=10) 23.53±4.73 6.60±1.78 0.943±0.277 28.54±9.41 134.45±54.68 5542.37±2244.70
P 0.064 0.704 0.265 0.637 0.648 0.594