2 What this study adds
No study has examined the effects of a combination of high-fat diet andCYP2B6 genotypes on the pharmacokinetics of BUP and HBUP among Chinese subjects.
The maximum plasma concentration and absorptive extent of BUP were enhanced by the intake of high-fat breakfast. The maximum absorption time of BUP was delayed and the speed of absorption was lower in the feeding condition than in the fasting condition.
Under the same feeding condition, the absorption of BUP and metabolism of HBUP were not influenced in the CYP2B6*1/*1 and CYP2B6mutants. For the same genotypes, the pharmacokinetic parameters ofCYP2B6*1/*1 subjects were obviously affected by high-fat diet, while those of CYP2B6 mutants showed the opposite trend.