Abrus precatorius
|
Seed extract
|
Abrus agglutinin (AGG)
|
p73 suppressed Snail expression, leading to EMT inhibition
Induction of intrinsic and extrinsic apoptosis
Inactivation of Wnt/β-catenin signaling pathway
|
50 μg/kg
|
Oral squamous cell carcinoma cells and xenografted nude mice
|
Sinha et al., 2017, 2019
|
Celandine
(TCM)
|
——
|
Sanguinarine
|
Downregulation of Wnt/β-catenin signaling pathway
|
0.5 mg/20 g
|
Lung CSCs and xenografted nude mice
|
Yang et al., 2016
|
Gynura divaricata subsp. formosana
|
Aqueous extract of aerial part
|
——
|
Downregulation of Wnt/β-catenin signaling pathway
|
300 mg/kg
|
Hepatocellular CSCs and xenograft mice model
|
Yen et al., 2018
|
Panax quinquefolius
|
——
|
Ginsenoside-Rb1
|
Inhibition of Wnt/β-catenin signaling
Inhibition of EMT
|
50 mg/kg
|
Ovarian CSCs and mouse xenograft models
|
Deng et al., 2017
|
Allium sativum
(Garlic)
|
——
|
Diallyl-trisulfide
|
Induction of apoptosis
Modulation of Wnt/β-catenin signaling pathway
|
——
|
Colorectal CSCs
|
Zhang et al., 2018
|
Murraya koenigii(L) Spreng
|
Leaf extract
|
Koenimbin
|
Induction of apoptosis by intrinsic pathway
Downregulation of Wnt/β-catenin self-renewal pathway
|
——
|
Breast CSCs
|
Kamalidehghan et al., 2015
|
|
|
|
Induction of apoptosis via intrinsic pathway
G0/G1 phase arrest
|
——
|
Prostate CSCs
|
Kamalidehghan et al., 2018
|
Rhodiola crenulata
|
Root extract
|
——
|
Decreased β-catenin expression
|
20 mg/kg
|
MCF-7 Estrogen
receptor positive (ER+) breast cancer cells and mouse xenograft
model
|
Bassa et al., 2016
|
Chelidonium majus/Macleaya cordata
|
——
|
Chelerythrine chloride
|
Downregulation of β-catenin
|
——
|
Non-small cell
lung carcinoma stem-like cells
|
Heng & Cheah, 2020
|
Evodiae rutaecarpa
|
——
|
Evodiamine
|
Inhibition of Wnt Signaling
|
——
|
Gastric CSCs
|
Wen et al., 2015
|
Evodiae fructus
|
——
|
Evodiamine
|
Induction of apoptosis
Suppression of Notch and Wnt Signaling
|
——
|
Colon CSCs
|
Kim et al., 2019
|
Baizuan
(TCM)
|
——
|
Gomisin M2
|
Downregulation of Wnt/β-catenin signaling pathway
Induction of apoptosis
|
10 μM
|
Breast CSCs and zebrafish xenograft
|
Yang et al., 2019
|
Cruciferous
vegetables
|
——
|
Sulforaphane (SFN)
|
Downregulation of DNA methyltransferase1 (DNMT1)
Restoring the expression of Wnt inhibitory factor 1 (WIF1)
|
60 mg/kg
|
Nasopharyngeal carcinoma cells and nude mice xenograft
|
Chen et al., 2019
|
|
|
|
Suppression of miR-19 and Wnt/β-catenin pathway
|
——
|
Lung CSCs
|
Zhu et al., 2017
|
|
|
|
Modulation of Sonic hedgehog–GLI pathway
Inhibition of pluripotency markers, angiogenesis markers and EMT
markers
|
——
|
Pancreatic CSCs
|
Li et al., 2013
|
Curcuma longa (Turmeric)
|
——
|
Curcumin
|
Suppression of Sonic Hedgehog pathway
Induction of apoptosis
Decreased expression of CSC markers
|
——
|
Bladder CSCs
|
Wang et al., 2017
|
Withania somnifera
(Ashwagandha)
|
Leaf extract
|
Withaferin A
|
Hh signal inhibition
|
——
|
Human pancreatic (PANC-1), prostate
(DU145) and breast (MCF7) cancer cells
|
Yoneyama et al., 2015
|
Magnolia
|
——
|
Honokiol (HNK)
|
Decreased expression of sonic hedgehog and CXCR4
Inhibition of NF-κB
|
150 mg/kg
|
Pancreatic cancer cells and nude mice xenograft
|
Averett et al., 2016
|
BRM270
|
Alcohol extract
|
——
|
Suppression of Sonic Hedgehog pathway
Induction of apoptosis
|
5mg/kg
|
Pancreatic ductal adenocarcinoma stem cells and nude mice
xenograft
|
Huynh et al., 2019
|
Qingyihuaji
(TCM)
|
——
|
Baicalein
|
Modulation of Sonic Hedgehog pathway
|
20 or 60 mg/kg
|
Pancreatic CSCs and mice xenograft
|
Song et al., 2018
|
Qingyihuaji
(TCM)
|
Water extract
|
——
|
Downregulation of Notch-4 and Jagged-1 in Notch signaling pathway
|
36 g/kg
|
Pancreatic cancer nude mice xenograft
|
Yanli et al., 2015
|
Xiaotansanjie
(TCM)
|
——
|
——
|
Inhibition of Notch-1
|
1.46, 2.92 and 5.84 g/mL
|
Gastric CSCs and mouse xenografts
|
Yan, 2014
|
Psoralea corylifolia
|
——
|
Psoralidin
|
Inhibition of Notch-1 signaling
Inhibition of EMT
|
——
|
Breast CSCs
|
Suman et al., 2013
|
PienTze Huang
(TCM)
|
——
|
——
|
Induction of apoptosis
Suppression of Notch-1 signaling pathway
|
——
|
Colorectal CSCs
|
Qi et al., 2016
|
MSC500
|
——
|
——
|
Suppression of ALDH, ABCB5, Oct-4, Sox-2, β-catenin, Gli-1, and
Notch-1
|
——
|
Glioblastoma stem cells
|
Yao et al., 2014
|