Notch pathway
When Notch ligand (Delta-like-1, DLL3, DLL4, Jagged1, or JAG2) binds to
its receptor (Notch1-4), ADAM/TACE and γ-secretase commence the
proteolytic cleavage of the cytoplasmic domain of the receptor. This
dual cleavage causes the release of Notch intracellular domain (NICD)
into the cytoplasm. It then translocates to the nucleus and activates
transcription of target genes via the CBF1, Suppressor of Hairless,
LAG-1/recombination signal binding protein for immunoglobulin k J region
(CSL/RBPJ) transcription factor (Karamboulas & Ailles, 2013) .