4.2. Phytomedicines targeting Notch signaling pathway
Qingyihuaji formula, a TCM, composed of Herba Scutellariae Barbatae , Herba Hedyotdis , Herba seu Radix, Rhizoma Arisaematis Erubescentis , Gynostemmatis Pentaphylli andFructus Amomi Rotundus downregulated Notch pathway as reported in a study and 36 g/kg dose of this compound increased the survival of pancreatic cancer mouse xenografts (Yanli et al., 2015) . Similarly, 1.46, 2.92 and 5.84 g/mL doses of Xiaotan Sanjie, a TCM showed suppression of Notch pathway and reduced tumor in gastric cancer xenograft models. Also, Pien Tze Huang exhibited modulation of Notch pathway in colorectal CSCs (Yan, 2014) . Suman et al., demonstrated that Psoralidin suppresses breast CSC by targeting NOTCH1-induced EMT (Suman et al., 2013) .