4. Preclinical research on phytomedicines targeting Wnt, Notch
and Hedgehog signaling in CSCs
Wnt, Notch and Hedgehog signaling pathways are responsible for stem-like
character of cancer cells and account for their self-renewal. Hence,
compounds targeting these pathways could provide a way out in designing
therapeutics as shown in Figure 4 (Hermawan & Putri, 2018) .