TCM: Traditional Chinese Medicine
Morusin, present in roots of Morus australis attenuated NF-κB activity in cervical CSCs, thus killing these tumor cells (L. Wang et al., 2013) . Bushenshugan, a TCM inhibited EMT through PI3K/AKT/NF-κB pathway, induced apoptosis and caused cell cycle arrest in G2/M phase in lung cancer cells (Fan et al., 2018) . Glabridin, obtained from root extract of Glycyrrhiza glabraexhibited epigenetic regulation of miR-148a/SMAD2 signaling and increased the survival of breast cancer mouse xenografts with 20 mg/kg dose of Glabridin (Jiang et al., 2016) .
ABC transporters are membrane proteins that act as efflux pumps, pumping out anti-cancer drugs and hence increase resistance to treatment(Yadav & Desai, 2019) . ABC transporter genes like ABCG2 and ABCB5 are often found to be upregulated in cancers of pancreas, breast, lung, ovary and skin and can be potential target for therapy(Makena et al., 2020) . PienTze Huang, a TCM consisting ofMoschus , Calculus Bovis , Snake Gall and Radix Notoginseng was shown to inhibit ABCB1 and ABCG2 in colorectal CSCs(Wei et al., 2014) .