Notch pathway
When Notch ligand (Delta-like-1, DLL3, DLL4, Jagged1, or JAG2) binds to its receptor (Notch1-4), ADAM/TACE and γ-secretase commence the proteolytic cleavage of the cytoplasmic domain of the receptor. This dual cleavage causes the release of Notch intracellular domain (NICD) into the cytoplasm. It then translocates to the nucleus and activates transcription of target genes via the CBF1, Suppressor of Hairless, LAG-1/recombination signal binding protein for immunoglobulin k J region (CSL/RBPJ) transcription factor (Karamboulas & Ailles, 2013) .