Prenatal SHS exposure AD phenotypes (reference group: non-AD) AD phenotypes (reference group: non-AD) AD phenotypes (reference group: non-AD) AD phenotypes (reference group: non-AD) AD phenotypes (reference group: non-AD) AD phenotypes (reference group: non-AD)
Non-AD (ref.) vs. Early transient Non-AD (ref.) vs. Early transient Non-AD (ref.) vs. Early transient Non-AD (ref.) vs. Early persistent Non-AD (ref.) vs. Early persistent Non-AD (ref.) vs. Early persistent Non-AD (ref.) vs. Late onset Non-AD (ref.) vs. Late onset Non-AD (ref.) vs. Late onset
N=1090 N=1090 N=1090 N=1133 N=1133 N=1133 N=1014 N=1014 N=1014
aOR 95% CI 95% CI aOR 95% CI 95% CI aOR 95% CI 95% CI
No 1.00 (ref) 1.00 (ref) 1.00 (ref)
Yes 1.127 0.801 1.586 1.012 0.735 1.394 1.663 1.038 2.664
Cotinine level N=372 N=372 N=372 N=384 N=384 N=384 N=347 N=347 N=347
aOR 95% CI 95% CI aOR 95% CI 95% CI aOR 95% CI 95% CI
Low 1.00 (ref) 1.00 (ref) 1.00 (ref)
High 1.147 0.582 2.261 1.516 0.765 3.005 2.884 0.834 9.975
Early transient phenotype, AD onset within 2 years of age, and no further symptoms. Early persistent phenotype, AD onset within 2 years of age, and symptoms did not improve within 2 years. Late-onset phenotype, AD onset after 2 years of age. Logistic regression, adjusted for maternal education level, sex of the children, the type of milk during the first 6 months of life, SHS exposure during the first year of life, parental history of allergic disease, the presence of a pet during the first year of life, attendance of daycare during the first year of life, and mode of delivery. Early transient phenotype, AD onset within 2 years of age, and no further symptoms. Early persistent phenotype, AD onset within 2 years of age, and symptoms did not improve within 2 years. Late-onset phenotype, AD onset after 2 years of age. Logistic regression, adjusted for maternal education level, sex of the children, the type of milk during the first 6 months of life, SHS exposure during the first year of life, parental history of allergic disease, the presence of a pet during the first year of life, attendance of daycare during the first year of life, and mode of delivery. Early transient phenotype, AD onset within 2 years of age, and no further symptoms. Early persistent phenotype, AD onset within 2 years of age, and symptoms did not improve within 2 years. Late-onset phenotype, AD onset after 2 years of age. Logistic regression, adjusted for maternal education level, sex of the children, the type of milk during the first 6 months of life, SHS exposure during the first year of life, parental history of allergic disease, the presence of a pet during the first year of life, attendance of daycare during the first year of life, and mode of delivery. Early transient phenotype, AD onset within 2 years of age, and no further symptoms. Early persistent phenotype, AD onset within 2 years of age, and symptoms did not improve within 2 years. Late-onset phenotype, AD onset after 2 years of age. Logistic regression, adjusted for maternal education level, sex of the children, the type of milk during the first 6 months of life, SHS exposure during the first year of life, parental history of allergic disease, the presence of a pet during the first year of life, attendance of daycare during the first year of life, and mode of delivery. Early transient phenotype, AD onset within 2 years of age, and no further symptoms. Early persistent phenotype, AD onset within 2 years of age, and symptoms did not improve within 2 years. Late-onset phenotype, AD onset after 2 years of age. Logistic regression, adjusted for maternal education level, sex of the children, the type of milk during the first 6 months of life, SHS exposure during the first year of life, parental history of allergic disease, the presence of a pet during the first year of life, attendance of daycare during the first year of life, and mode of delivery. Early transient phenotype, AD onset within 2 years of age, and no further symptoms. Early persistent phenotype, AD onset within 2 years of age, and symptoms did not improve within 2 years. Late-onset phenotype, AD onset after 2 years of age. Logistic regression, adjusted for maternal education level, sex of the children, the type of milk during the first 6 months of life, SHS exposure during the first year of life, parental history of allergic disease, the presence of a pet during the first year of life, attendance of daycare during the first year of life, and mode of delivery. Early transient phenotype, AD onset within 2 years of age, and no further symptoms. Early persistent phenotype, AD onset within 2 years of age, and symptoms did not improve within 2 years. Late-onset phenotype, AD onset after 2 years of age. Logistic regression, adjusted for maternal education level, sex of the children, the type of milk during the first 6 months of life, SHS exposure during the first year of life, parental history of allergic disease, the presence of a pet during the first year of life, attendance of daycare during the first year of life, and mode of delivery. Early transient phenotype, AD onset within 2 years of age, and no further symptoms. Early persistent phenotype, AD onset within 2 years of age, and symptoms did not improve within 2 years. Late-onset phenotype, AD onset after 2 years of age. Logistic regression, adjusted for maternal education level, sex of the children, the type of milk during the first 6 months of life, SHS exposure during the first year of life, parental history of allergic disease, the presence of a pet during the first year of life, attendance of daycare during the first year of life, and mode of delivery. Early transient phenotype, AD onset within 2 years of age, and no further symptoms. Early persistent phenotype, AD onset within 2 years of age, and symptoms did not improve within 2 years. Late-onset phenotype, AD onset after 2 years of age. Logistic regression, adjusted for maternal education level, sex of the children, the type of milk during the first 6 months of life, SHS exposure during the first year of life, parental history of allergic disease, the presence of a pet during the first year of life, attendance of daycare during the first year of life, and mode of delivery. Early transient phenotype, AD onset within 2 years of age, and no further symptoms. Early persistent phenotype, AD onset within 2 years of age, and symptoms did not improve within 2 years. Late-onset phenotype, AD onset after 2 years of age. Logistic regression, adjusted for maternal education level, sex of the children, the type of milk during the first 6 months of life, SHS exposure during the first year of life, parental history of allergic disease, the presence of a pet during the first year of life, attendance of daycare during the first year of life, and mode of delivery.